TY  - JOUR
T1  - Containment before Release: Designing Reversible, Localized, and Threshold-Dependent Genetic Strategies for Mosquito Population Control
A1  - Johan Mertens
A1  - Sylvie Dubois
A1  - Pieter De Smet
A1  - Lukas Wouters
JF  - Entomology and Applied Science Letters
JO  - Entomol Appl Sci Lett
SN  - 2349-2864
Y1  - 2026
VL  - 13
IS  - 2
DO  - 10.51847/FERaG9ZVOv
SP  - 55
EP  - 65
N2  - Genetic mosquito control can amplify an intervention through inheritance, creating a distinctive mismatch between the location of release and the eventual scale of exposure. This article develops a containment-first decision architecture for assessing genetic strategies before environmental release. The contribution is conceptual and evidence-grounded rather than empirically validated. It distinguishes temporal self-limitation, release-threshold dependence, spatial localization, molecular interruption, ecological recovery, and institutional authorization as related but non-equivalent constructs. The analysis argues that containment cannot be inferred from a construct label or a successful cage outcome. Instead, a defensible claim requires evidence about multigeneration persistence, migration sensitivity, threshold robustness, ecological pathways, evolutionary failure, countermeasure feasibility, monitoring power, and governance capacity. A sequence of pre-release gates is proposed to convert these evidence domains into explicit decision records while preserving a separate authorization boundary. The architecture also links post-release observations to redesign, pause, stop, remediation, and recovery obligations. Its central proposition is that genetic mosquito control should move toward open-environment testing only when the expected exposure envelope, residual uncertainty, and feasible response options are jointly specified. The architecture remains non-validated and should be evaluated through retrospective case analysis, prospective contained studies, and jurisdiction-specific governance research.
UR  - https://easletters.com/article/containment-before-release-designing-reversible-localized-and-threshold-dependent-genetic-strateg-avbmiztkwpzfk6n
ER  -