TY  - JOUR
T1  - From Insecticidal Plants to Reliable Bioproducts: A Scoping Review of Discovery, Standardization, Formulation, and Regulatory Translation
A1  - Ravi Kumar
A1  - Neha Sharma
A1  - Aniket Deshmukh
A1  - Arjun Nair
JF  - Entomology and Applied Science Letters
JO  - Entomol Appl Sci Lett
SN  - 2349-2864
Y1  - 2025
VL  - 12
IS  - 1
DO  - 10.51847/gge6K8YhDy
SP  - 17
EP  - 29
N2  - Botanical insecticides offer chemically diverse starting points for insect control, but evidence of plant-derived bioactivity frequently fails to mature into reproducible, safe, and registrable bioproducts. The central problem is not a shortage of promising plants; it is the fragmentation of evidence across source selection, chemical identity, mechanism, standardization, formulation, stability, non-target assessment, and regulatory translation. This original scoping review maps those evidence domains and examines where apparently continuous development pathways contain non-equivalent evidentiary steps. The review uses predefined questions and boundaries to chart recent peer-reviewed evidence by material type, biological scale, study design, translation stage, inferential strength, and principal limitation. The synthesis indicates that ethnobotanical knowledge and laboratory screening can prioritize candidates, while chemical profiling, fraction or constituent testing, and target-oriented experiments can progressively strengthen attribution. However, crude-extract activity does not establish an identified active principle, and mechanistic plausibility does not by itself establish reproducible product performance. Likewise, formulation can improve delivery or persistence while simultaneously changing exposure and safety requirements. The literature is limited by heterogeneous materials and assays, mortality-centred endpoints, incomplete provenance and chemotype reporting, laboratory dominance, and sparse linkage between chemical specifications and retained efficacy under realistic conditions. A defensible development strategy therefore requires stage-gated evidence in which botanical identity, quantitative chemistry, biological performance, formulation behaviour, non-target effects, and regulatory requirements are evaluated as connected but distinct constructs. Reliable botanical bioproducts will depend less on accumulating additional activity reports than on producing interoperable evidence that supports reproducibility, bounded claims, and transparent decisions at each translation stage.
UR  - https://easletters.com/article/from-insecticidal-plants-to-reliable-bioproducts-a-scoping-review-of-discovery-standardization-fo-e0ljargtpzqxa6c
ER  -