TY  - JOUR
T1  - Literature Review: The Efficacy of Glucocorticoids in IgA Nephropathy Patients
A1  - Yousef Jebrin Aljebrin
A1  - Abdulrahman Abdulmohsen Bin Rashed
A1  - Munthir Abdullah Alahmed
A1  - Jumana Hamid Alsamadani
A1  - Fatine Mahamat Ali Mahamat
A1  - Aifan Saad E Alrsheedi
A1  - Abdulmajeed Abdullah Alshammari
A1  - Abdullah Mohammed Ghaith
A1  - Ibrahim Kaluffah Alkhathami
A1  - Ali Mohammed Alsubaiei
A1  - Sami Ibrahim Alowibedi
A1  - Wijdan Abdulaziz Sheqdar
JF  - Entomology and Applied Science Letters
JO  - Entomol Appl Sci Lett
SN  - 2349-2864
Y1  - 2021
VL  - 8
IS  - 2
DO  - 10.51847/mSqg8ILxvW
SP  - 85
EP  - 90
N2  - Primary most common cause of IgA nephropathy represents glomerulopathy worldwide. While initially thought this disease course was benign and self-limited, a few studies have appeared that it cause renal disease development and continued to end-stage renal disease in nearly one-third of the affected patients. IgA nephropathy is commonly actuated by autoimmune antigens targeting the glomerular mesangium, leading to IgA accumulation.  This literature review investigates the efficacy and safety of corticosteroids therapy in IgA nephropathy and provides an updated review of the disease mechanism and pathophysiology.  We used the PubMed database, searching for relevant articles on the topic. The following Mesh words were used: IgA nephropathy, corticosteroids, management, adverse effects. Several immunosuppressive therapies were used in addition to standard management for IgA nephropathy. Corticosteroids seem to provide more beneficial effects than other agents, and some studies addressed this efficacy when corticosteroids are added to other immunosuppressive agents. Nonetheless, serious adverse events were reported in the steroids groups, such as serious infection, gastrointestinal symptoms and bleeding, diabetes mellitus, and impaired glucose intolerance. These serious adverse events cannot be ignored and must be encountered seriously in future clinical trials.
UR  - https://easletters.com/article/literature-review-the-efficacy-of-glucocorticoids-in-iga-nephropathy-patients-stiw0nwjx86siws
ER  -