%0 Journal Article
%T Pantohematogen Safety Study: Embryotoxicity or Teratogenicity
%A Galina Arkadevna Dorn
%A Valeriy Mikhailovich Poznyakovsky-
%A Nadezhda Nikolaevna Danko
%A Pastushkova Ekaterina Vladimirovna
%A Boisjoni Tokhiriyon
%J Entomology and Applied Science Letters
%@ 2349-2864
%D 2023
%V 10
%N 3
%R 10.51847/acBH7c5ZL5
%P 42-50
%X The research was aimed at examining the embryotoxic or teratogenic effects of pantohematogen, which is produced from velvet antlers of the Altai Wapiti and is used as a functional ingredient in a range of confectionery products. A total of 180 female Wistar rats were studied. During the study, the rats were administered different doses of the experimental solution, although, no significant differences in either appearance or behaviour were observed. The findings of the study indicate that pantohematogen neither affects fertility nor increases embryonic death. However, the female pups from the dams injected with the subtoxic dose of the experimental solution demonstrated delayed puberty. With a lower dose of the experimental solution, no delays in the onset of puberty were observed. The findings of the research suggest that pantohematogen does not possess any undesirable properties and is safe to use as a functional ingredient. The research was performed at Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Centre of the Russian Academy of Sciences, and supervised by Tatyana G. Borovskaya, D.Sc., Professor, Head of the Laboratory of Pharmacology of the Reproductive System.
%U https://easletters.com/article/pantohematogen-safety-study-embryotoxicity-or-teratogenicity-adpxc6yj668djic