2016 Volume 3 Issue 4

Microextraction and determination trace of doxycycline in aqueous samples with CuO nanoparticles by spectrophotometry


Najmeh Dibaei, Mahmoud Ebrahimi, Abolghasem Davoodnia
Abstract

In this work, The CuO nanoparticles were characterized which developed a novel CuO nanoparticle-assisted matrix solid-phase dispersion (CuO-MSPD) method for extraction of doxycycline (DC) from environmental samples. Spectrophotometric determination was developed for isolation and pre-concentration of doxycycline form aquatic and CuO nanoparticles (NPs) was used as a sorbent. The unique properties of CuO NPs including high surface area was utilized effectively in the MSPE process. The effect of the different parameters such as pH, extraction time, effect of the salt, nanoparticle amount and extraction temperature have been studied. Under optimized condition, the method was successfully applied to the extraction of DC from aqueous samples and relative recovery amount of 87%, detection limit of 25μg L-1 and a relative standard deviation (RSD) of 2.3% were obtained. The method linear response was over a range of 10–50000μgL−1 with R2 = 0.9968. The relative recovery in aqueous matrices was investigated and values of 89% were obtained. The whole procedure showed to be conveniently fast and high extraction efficiency of DC from real samples.

 

Keywords: Doxycycline, spectrophotometry, nanoparticles, antibiotic;


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Entomology and Applied Science Letters is an international peer reviewed publication which publishes scientific research & review articles related to insects that contain information of interest to a wider audience, e.g. papers bearing on the theoretical, genetic, agricultural, medical and biodiversity issues. Emphasis is also placed on the selection of comprehensive, revisionary or integrated systematics studies of broader biological or zoogeographical relevance. Papers on non-insect groups are no longer accepted. In addition to full-length research articles and reviews, the journal publishes interpretive articles in a Forum section, Short Communications, and Letters to the Editor. The journal publishes reports on all phases of medical entomology and medical acarology, including the systematics and biology of insects, acarines, and other arthropods of public health and veterinary significance.
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