%0 Journal Article
%T Ameliorative Effects of Urtica dioica Aqueous Extract against Hepatotoxicity and Nephrotoxicity Induced by Insecticide Mixture in Adult Male Rats
%A Mongi Saoudi
%A Fatma Rahmouni
%A Malek El Aroui
%A Mariem Boudaya
%A Kamel Jamoussi
%A Choumous Kallel
%A Abdelfattah El Feki
%J Entomology and Applied Science Letters
%@ 2349-2864
%D 2020
%V 7
%N 3
%P 98-110
%X The present study was conducted to investigate the protective effects of Urtica dioica (U. dioica) against hepatotoxicity and nephrotoxicity induced by insecticide mixture deltamethrin (DLM) and chlorpyrifos (CPF). The rats were divided into five experimental groups: the control group, the group treated with deltamethrin and chlorpyrifos insecticide mixture, the group received a mixture of vitamins CE and insecticide mixture (deltamethrin and chlorpyrifos), the group received an aqueous extract of U. dioica and the group treated with the aqueous extract of U. dioica and simultaneously receive the mixture of deltamethrin and chlorpyrifos. U. dioica was found to contain large amounts of polyphenols (712.37µg/g GAE/mg of a dry plant). DLM/CPF induced a disturbance of red blood cells (RBC), hemoglobin (HB), and hematocrit (Ht), an increase in aspartate aminotransferase (ASAT), alanine aminotransferase (ALAT), lactate dehydrogenase (LDH), Alkaline phosphatase (ALP), creatinine, urea and uric acid levels, a significant increase in thiobarbituric acid reactive substances (TBARS), conjugated diene (CD), carbonyl protein (CP) and advanced oxidation of protein products (AOPP) levels. Our results revealed that U.dioica has a therapeutic effect on some health problem and has an important antioxidant and antiradical activity.
%U https://easletters.com/article/ameliorative-effects-of-urtica-dioica-aqueous-extract-against-hepatotoxicity-and-nephrotoxicity-induced-by-insecticide-mixture-in-adult-male-rats