Toxicity Effect of Nectaroscordum tripedale Extract on Hematological and Biochemical Parameters in Mice

Currently, a broad spectrum of medicinal herbs is existing; while this seems to be necessary to present scientific validations for finding their side effects for therapeutic goals. In this study, the toxicity effects of Nectaroscordum tripedale extract on hematological and biochemical parameters in mice were assessed. Toxicity effects of N. tripedale extract was assessed by measuring the biochemical and hematological parameters of the treated mice after oral administration of N. tripedale extract at the doses of 0.5, 1, and 2 g/kg, respectively, for two weeks. The obtained results of the present investigation revealed that N. tripedale extract at the tested doses had no significant toxicity on the biochemical parameters of ALT, AST, ALP, and bilirubin for the liver function, and also Cr and BUN for renal function as well as hematological parameters such as HGB, Hct, WBC, RBC, and PLT counts. However additional studies are mandatory to assess other toxicity aspects such as genotoxicity, chronic toxicity.

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