%0 Journal Article %T ‎Study of the Effect of HBX Gene of Hepatitis B Virus on Liver Cancer Progress %A ‎ Mahla Khosravi Mashizi %A Alijan Tabaraei Golestan %J Entomology and Applied Science Letters %@ 2349-2864 %D 2020 %V 7 %N 3 %P 55-65 %X Liver cancer is the fifth most common cancer worldwide in men and women. It is also the second most common cause of cancer mortality rate. Hepatocellular carcinoma (HCC) is one of the most common types of liver cancer. According to the studies worldwide, About 350 million people have chronic HBV disease. At least 60% of HCC cases worldwide are due to chronic hepatitis B virus (HBV) infection. Other non-HBV factors may increase the risk of HCC among persons with chronic HBV infection. Both indirect and direct methods are involved in HCC oncogenesis by HBV. HCC-promoting HBV factors include lasting infection, high levels of HBV replication, HBV genotype, HBV integration, specific HBV mutants, and HBV-encoded oncoproteins (e.g., HBx and truncated preS2/S proteins). Recurrent liver inflammation which is caused by host immune responses during chronic HBV infection can lead to liver fibrosis and cirrhosis, accelerating hepatocyte turnover rate, and accumulating mutations. Major advances in the prevention of HBV-associated HCC with HBV vaccines and antiviral therapies have been made. %U https://easletters.com/article/study-of-the-effect-of-hbx-gene-of-hepatitis-b-virus-on-liver-cancer-progress