%0 Journal Article
%T The evaluation of cytotoxicity effects of Rheum ribes L. (rubarb) extract on cancer cell lines and its antibacterial and mutagenicity activity
%A Mozhgan Azadpour
%A Mohammad Morad Farajollahi
%A Ali Mohamad Varzi
%A Frouzan Hadipour
%A Mitra Barati
%J Entomology and Applied Science Letters
%@ 2349-2864
%D 2020
%V 7
%N 3
%P 7-12
%X Background: Some medicinal herbs have excellent antibacterial and cytotoxic effects against bacteria and cancer cells, respectively. Because some of these herbs are potentially toxic to patients, evaluation of their safety before use for treatment is essential. This study aims to evaluate the cytotoxicity effects of Rheum ribes L. (rubarb) extract on cancer cell lines and its antibacterial and mutagenicity activity. Methods: In this study, MTT assay was used to evaluate the cytotoxic effect of Rubarb extract. Also, MBC and MIC were calculated to evaluate the antibacterial effect of this extract. Ames test was used for the potential of genotoxic (mutagenic) assay. Result: The results showed that Rubarb extract had a cytotoxic effect against KB and A549 cancer cell lines at different concentrations (39, 78, 156, 312, 625 and 1250 mg/ml). It also had antibacterial activity against some optional gram-positive and gram-negative bacteria. It had the greatest inhibitory effect against Streptococcus agalactiae. Also, it was shown that this extract did not cause mutation and DNA damage. Conclusion: Finally, using rubarb for the treatment of cancer patients can be a good treatment strategy because of its safety and lack of genotoxicity for normal cells of the body.
%U https://easletters.com/article/the-evaluation-of-cytotoxicity-effects-of-rheum-ribes-l-rubarb-extract-on-cancer-cell-lines-and-its-antibacterial-and-mutagenicity-activity