Can the level of vitamin D be a predictor for the risk of cutaneous lupus erythematous? Case study: Razi Hospital in 2014

Sahar Rabani Khorasgani, Pedram Normohammadpour, Mohammad Ali Mansournia

Abstract


Low level of vitamin D, as an immunomodulator factor, is found in autoimmune diseases. Cutaneous lupus patients, because of exacerbation due to sun exposure, need to protect from the sun. This is while the main source of vitamin D is exposure to sunlight. The aim of this study was to evaluate the relation between cutaneous lupus and serum level of vitamin D. In a cross-sectional study, the random sample of 20 cutaneous lupus patients from Razi hospital, Tehran, Iran in 2014 and 20 people as a control group were compared for serum vitamin D levels (by matching age, sex and season). The 30% of cutaneous lupus patients had vitamin D deficiency (<10 ng/ml) and 80% had either deficiency or insufficiency (<30 ng/ml); While in the control group there was no deficiency and 60% of people had vitamin D insufficiency. The average serum level of vitamin D in patients was 20.07±12.39 ng / ml and in healthy individuals was 30.15±17.05 ng / ml. The serum level of vitamin D in patients was significantly lower than the control group (p value = 0.039).Increasing 5ng/ml vitamin D, decreased 22% the risk of cutaneous lupus. Sun protection did not change the serum level of vitamin D in patients. So it seems that vitamin D deficiency in cutaneous lupus patients is more related to the nature of the disease. In this respect, the vitamin D level measurement is recommended to be used as a screening test to prevent complications in these patients.

 

Key words: Vitamin D, Cutaneous lupus erythematosus, Systemic lupus erythematosus, photosensitivity


Full Text:

PDF

References


Hansen CB, Dahle KW. Dermatologic Therapy 2012; 25: 99–111.

Holick MF. Clinic Rev Bone Miner Metab 2009; 7:2–19.

Heine G, Lahl A, Muller C, Worm M. BJD 2010;163:863–5.

Cutillas-Marco E, Morales-Sua´rez-Varela MM, Marquina-Vila A, GrantWB. Lupus 2010;19:810–4.

Malabanan A, Veronikis IE, Holick MF. The Lancet 1998; 351:805-6.

Endocrine society. Is vitamin D recommendation too high? Available at:http://press.endocrine.org/eletters/

1210/jc.2011-0385. accessed: Aug 3 2011.

Munoz LE, Schiller M, Zhao Y, Voll RE, Schett G, Herrmann M. Rheumatology 2012;51:585-587.

Cutillas-Marco E, Marquina-Vila A, Grant W, Vilata-Corell J, Morales-Suárez-Varela M. Lupus 2014; 23: 615-23.

Sahebari M, NabaviN, SalehiM. Lupus 2014;23:1164-1177.

Renne J, Werfel T, Wittmann M. BJD 2008;159:386-387.

Cusack C, Danby C, Fallon J, Lyn Ho W, Murray B, Brady J, et al. Photodermatology, Photoimmunology & Photomedicine March 2008;24:260–7.

Holick MF. N Engl J Med 2007;357:266-81.

Holick MF. Lancet 2001;357:4–6.

Vickery E, Thobani A, Delong L, Murthy R. J AM AcadDermatol 2014;70: AB60.




URN: http://nbn-resolving.de/urn:nbn:de:0000easl.v3i3S.1169

Refbacks

  • There are currently no refbacks.




Copyright (c) 2017 Entomology and Applied Science Letters



<Entomology+Zoology+Allied Branches>Entomology and Applied Science Letters