Can the level of vitamin D be a predictor for the risk of cutaneous lupus erythematous? Case study: Razi Hospital in 2014

Sahar Rabani Khorasgani, Pedram Normohammadpour, Mohammad Ali Mansournia


Low level of vitamin D, as an immunomodulator factor, is found in autoimmune diseases. Cutaneous lupus patients, because of exacerbation due to sun exposure, need to protect from the sun. This is while the main source of vitamin D is exposure to sunlight. The aim of this study was to evaluate the relation between cutaneous lupus and serum level of vitamin D. In a cross-sectional study, the random sample of 20 cutaneous lupus patients from Razi hospital, Tehran, Iran in 2014 and 20 people as a control group were compared for serum vitamin D levels (by matching age, sex and season). The 30% of cutaneous lupus patients had vitamin D deficiency (<10 ng/ml) and 80% had either deficiency or insufficiency (<30 ng/ml); While in the control group there was no deficiency and 60% of people had vitamin D insufficiency. The average serum level of vitamin D in patients was 20.07±12.39 ng / ml and in healthy individuals was 30.15±17.05 ng / ml. The serum level of vitamin D in patients was significantly lower than the control group (p value = 0.039).Increasing 5ng/ml vitamin D, decreased 22% the risk of cutaneous lupus. Sun protection did not change the serum level of vitamin D in patients. So it seems that vitamin D deficiency in cutaneous lupus patients is more related to the nature of the disease. In this respect, the vitamin D level measurement is recommended to be used as a screening test to prevent complications in these patients.


Key words: Vitamin D, Cutaneous lupus erythematosus, Systemic lupus erythematosus, photosensitivity

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