Wound healing potential of various successive fractions obtained from Aegle marmelos (AM) and Mucuna pruriens (MP) in acid burn wound models: An experimental animal study

Fedelic Ashish Toppo, Rajesh Singh Pawar


Traditionally leaves of Aegle marmelos (Linn.) Correa (Rutaceae) and seeds of Mucuna pruriens Linn. (Fabaceae) are applied on cuts and wounds. We report the acid burned wound healing activities of sequential ethyl acetate, methanol and aqueous extracts of AM and MP in acid burn wound models in rats. Forty-eight Wistar-albino rats (220±20g) were divided into eight groups (n=6) and were subjected to acid burn (100 mm2) on the back of their necks. Animals were divided into control group, standard group and treatment groups. The hydrogel was applied topically once daily to the treatment groups. The parameters observed were epithelialization period, wound contraction % and histopathological analysis as indicative of the process of healing. After the 20th day of treatment, wound closure % was 77.75% in control group, for the standard group it was 100%, for the test group III, IV, V, VI, VII and VIII it was 86.21, 94.81, 93.43, 89.66, 94.63 and 80.74%,respectively.Test groups III,IV,VI and VII showed significant (p<0.01)improvement in wound contraction % in comparison to control group. Similarly the period of epithelialization also decreased significantly in test groups. All extracts facilitated the wound healing process as demonstrated by a decrease in the period of epithelialization and faster wound contraction in acid burn wounds. Ethyl acetate and methanolic extract seemed to have the most active component for healing the acid burned wound.


Keywords: Rejuvenate; Bel; Kiwanch; Ameliorated acid burns; Wistar-albino rats

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URN: http://nbn-resolving.de/urn:nbn:de:0000easl.v3i5.1358


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