Anti-inflammatory and antinociceptive effects of Dolichandrone Falcata fruit extracts in animal models

Badgujar Vishal Bhagwan, Surana Sanjay J, Badgujar Sangita V

Abstract


Despite traditional claims about the pharmacological properties of Dolichandrone falcata and the successful isolation of bioactive compounds from its leaves, no in-depth scientific study has been carried out on their effects. The present study was carried out to determine the anti-inflammatory and antinociceptive activities of the methanol (DFFM) and ethyl acetate (DFFEA) extracts of Dolichandrone falcata fruits using animal models. An extract was obtained from air-dried, powdered fruits (900 g) using a Soxhlet extractor with methanol, it was then treated to obtain the ethyl acetate extract. The crude dried DFFM extract (90 g) and DFFEA extract (18 g) were used to prepare formulations, at doses of 100, 200 and 400 mg/kg, that were used in anti-inflammatory (carrageenan- and histamine-induced paw edema test) and antinociceptive (abdominal constriction, hot plate and tail flick tests) assays. The results obtained indicate that the extracts exhibited significant (P< 0.001) anti-inflammatory and antinociceptive effects, which were found to be dose dependent. The highest doses of both extracts were most significant and effective. This study showed that the methanol and ethyl acetate extracts of Dolichandronefalcata fruits possess potentially pharmacologically active constituents responsible for inhibition of inflammation and nociceptive effects.

 

Key Words: Bignoniaceae, Dolichandrone falcata, Anti-inflammatory, Antinociceptive


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References


D. Patil In:Flora of Dhule and Nandurbar districts (Maharashtra), Bishen Singh Mahendra Pal Singh Publishers

and Distributors of Scientific Books, Dehradun, 2003.

Asia Pacific Medicinal Plant Database Broader topics

G. M. Vidyasagar and P. Prashantkumar, Fitoterapia 2007,78,1, 48-51

S. Sankara Subramanian, S. Nagarajan and N. Sulochana, Phytochemistry 1972,11, 1, 438-439

J.-S. Shin, K.-S. Kim, M.-B. Kim, J.-H. Jeong and B.-K. Kim, Bioorganic & Medicinal Chemistry Letters 1999, 9,6, 869-874

N. Kumar, B. Singh, P. Bhandari, A. P. Gupta, S. K. Uniyal and V. K. Kaul, Phytochemistry 2005,66,23, 2740-2744

C. A. Winter, E. A. Risley and G. W. Nuss, Experimental Biology and Medicine 1962,111,3, 544-547

B. M. Moraes, B. C. do Amaral, M. S. S. Morimoto, L. G. C. Vieira, F. F. Perazzo and J. C. T. Carvalho, Inflammopharmacology 2007,15, 4, 175-178

K. D. Saneja A, Khokra SL, Kaushik P, Sharma C and Aneja KR, Journal of Natural Products 2009, 2, 49-54

G. Amresh, G. D. Reddy, C. V. Rao and P. N. Singh, Journal of Ethnopharmacology 2007, 110,3, 526-531

H. O. J. Collier, L. C. Dinneen, C. A. Johnson and C. Schneider, British Journal of Pharmacology and Chemotherapy 1968, 32, 2, 295-310

L. D. Eddy NB, J. Pharmacol. Exp. Therap1953, 107, 385–393

P. Malairajan, G. Geetha, S. Narasimhan and K. Jessi Kala Veni, Journal of Ethnopharmacology 2006, 106,3, 425-428

S. Aydin, T. Demir, Y. Öztürk and K. H. C. Başer, Phytother. Res.1999, 13, 1, 20-23

V. W. Vogel GH In: Drug discovery and evaluation and pharmacological assays, Springer, Berlin, 1997

L. R. Ballou, R. M. Botting, S. Goorha, J. Zhang and J. R. Vane, Proceedings of the National Academy of Sciences2000, 97, 18, 10272-10276

V. G. Pini LA, Ottani A and Sandrini M, J Pharmacol Exp Ther1997, 280, 934-940

Á. D. Uzcátegui B, Suárez-Roca H, Quintero L and Ortega J, González B Invest Clín2004, 45, 317-322

G. M. Bars D and Cadden SW,Pharmacol Rev2001, 53,597–652

R. Z. Maj J, Pol J Pharmacol2000, 52, 111–114

D. A. Gamache, J. T. Povlishock and E. F. Ellis, Journal of Neurosurgery1986, 65, 5, 679-685

Z. O. Attaway DH In:Pharmaceutical and Bioactive Natural Products, Plenum Press, New York 1993.

S. F. Robak J, Wolbis M and Krolikowska MPol,J Pharmacol Pharm1998, 40, 451–458

F. C. Meotti, Journal of Pharmacology and Experimental Therapeutics2005,316, 2, 789-796

L. D. Machelska H, Przewlocki R and Przewlocka B, J Pharmacol Exp Ther1997 ,282, 977–984

C. Ke Chen and C. R. Pace-Asciak, General Pharmacology1996, 27, 2, 363-366

N.-H. Nam, MRMC2006,6, 8, 945-951

B. Singh, M. K. Sharma, P. R. Meghwal, P. M. Sahu and S. Singh, Phytomedicine2003, 10, 5, 375-380

J. Silva, W. Abebe, S. M. Sousa, V. G. Duarte, M. I. L. Machado and F. J. A. Matos, Journal of Ethnopharmacology2003, 89, 2-3, 277-283




URN: http://nbn-resolving.de/urn:nbn:de:0000easl.v3i5.1585

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