Anti-inflammatory and antinociceptive effects of Dolichandrone Falcata fruit extracts in animal models

Badgujar Vishal Bhagwan, Surana Sanjay J, Badgujar Sangita V


Despite traditional claims about the pharmacological properties of Dolichandrone falcata and the successful isolation of bioactive compounds from its leaves, no in-depth scientific study has been carried out on their effects. The present study was carried out to determine the anti-inflammatory and antinociceptive activities of the methanol (DFFM) and ethyl acetate (DFFEA) extracts of Dolichandrone falcata fruits using animal models. An extract was obtained from air-dried, powdered fruits (900 g) using a Soxhlet extractor with methanol, it was then treated to obtain the ethyl acetate extract. The crude dried DFFM extract (90 g) and DFFEA extract (18 g) were used to prepare formulations, at doses of 100, 200 and 400 mg/kg, that were used in anti-inflammatory (carrageenan- and histamine-induced paw edema test) and antinociceptive (abdominal constriction, hot plate and tail flick tests) assays. The results obtained indicate that the extracts exhibited significant (P< 0.001) anti-inflammatory and antinociceptive effects, which were found to be dose dependent. The highest doses of both extracts were most significant and effective. This study showed that the methanol and ethyl acetate extracts of Dolichandronefalcata fruits possess potentially pharmacologically active constituents responsible for inhibition of inflammation and nociceptive effects.


Key Words: Bignoniaceae, Dolichandrone falcata, Anti-inflammatory, Antinociceptive

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