5% Suspension of Albendazole Echinacea Magenta (Echinacea Pur-purea) Toxicometric Evaluation

Lopteva Maria Sergeevna, Kolesnikov Vladimir Ivanovich, Pushkin Sergey Viktorovich, Povetkin Sergey Nikolaevich, Marinicheva Marina Petrovna, Strogov Vladimir Viktorovich, Nagdalian Andrey Ashotovich

Abstract


The acute toxicity of 5% suspension of albendazole Echinacea Magenta (Echinaceapurpurea) was studied when administered orally to outbred white mice. To determine the characteristics of the suspension acute toxicity, it was administered to animals once with varying doses. The general condition and behavior of animals were observed during 14 days. The intoxication symptoms’ manifestation and possible death were noticed. The animals' death was observed within five days after the drug administration. The drug's acute toxicity characteristics were as follows: MPD -740 mg/kg of body weight, and LD50 – 2960 mg/kg of body weight, LD16 -1450,4 mg/kg, LD84– 6050 mg/ kg of body weight. In accordance with Russian State Standard 12.1.007-76, the drug belonged to the class 3 of danger (moderately toxic substance).


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URN: http://nbn-resolving.de/urn:nbn:de:0000easl.v5i4.2792

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Copyright (c) 2019 Lopteva Maria Sergeevna, Kolesnikov Vladimir Ivanovich, Pushkin Sergey Viktorovich, Povetkin Sergey Nikolaevich, Marinicheva Marina Petrovna, Strogov Vladimir Viktorovich, Nagdalian Andrey Ashotovich

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<Entomology+Zoology+Allied Branches>Entomology and Applied Science Letters