Peculiarities of Phosphorine Calcium Exchange in the Pathogenesis of Dental Caries in Children with Diabetes of the First Typ

Dmitry Anatolyevich Domenyuk, Vladimir Alexandrovich Zelensky Alexandrovich Zelensky, Sergey Vladimirovich Dmitrienko, Oksana Ivanovna Anfinogenova, Pushkin Sergey Viktorovich

Abstract


The main purpose.Assessment of caries resistance of hard tissues of the teeth (oral cavity) and the state of phosphoric calcium metabolism in children with type 1 diabetes mellitus, taking into account the mineralizing potential of oral fluid and antimicrobial protection of the oral cavity.

Materials and methods. A general clinical, dental, laboratory examination of 127 children with type 1 diabetes mellitus, aged from 7 to 12 years, with an endocrinopathy experience of eight months to ten years was conducted. The obtained data were compared with the results of a survey of 37 "healthy" and "practically healthy" children of this age category. When assessing the dental status of children, a hygienic index was used (Y. A. Fedorov, V. V.Volodkina, 1970), the EC + kp index (EC- Expert Committee, 1962), the OHI-S simplified hygienic index (Green, Vermillion, 1964).The intensity of the enamel of teeth demineralization processes was assessed by using an enamel resistance test (V. R.Okushko, L. I. Kosareva, 1984), vital staining (coloring) (LA Aksamit, 1978). The electrometry of the hard tissues of the teeth was carried out by the electro-diagnostic apparatus of "Dent Est" (V. K.Leontiev, G. G.Ivanova, 1985). Laboratory diagnosis of salivary parameters included the study of calcium (total ionized), inorganic phosphorus, alkaline phosphatase, osteo-calcine, parathyroid hormone, 25 hydroxy-vitamin D3, lactoferrin. Micro-crystallization and mineralizing potential of the oral fluid were determined according to Leus P. A. (1977).

Results. In the early stages of development of type 1 diabetes, children have a compensated and sub-compensated form of the carious process, an increase in the permeability of the enamel, a slight predominance of demineralization processes in the solid tissues of the teeth over the processes of remineralization, which indicates self-regulation of the mechanisms of mineral metabolism while maintaining physiological re-mineralizing properties of the oral fluid.In the late stages of development of type 1 diabetes mellitus, high intensity and decompensated form of the course of carious lesions, low structural and functional resistance of enamel, expressed processes of demineralization of hard tooth tissues are established. The emergence of this complex in children with an endocrinopathy experience for more than five years indicates the depletion of salivary gland functionality, the violation of mobilization salivary systems in response to the occurrence of a cariogenic situation in the oral cavity, a change in calcium homeostasis, a decrease in enamel resistance to organic acids, saliva to crystallization.

The conclusion. The growing positive dynamics of index growth in children with long-term type 1 diabetes mellitus, indicating a worsening of the dental status, requires adherence to the principles of rational nutrition, quarterly professional dental caries with the use of modern and effective oral care products, the introduction of active forms of hygienic training and education, taking into account the mineralizing potential of oral fluid, as well as careful monitoring acquired manual skills.


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References


Munir, A. Malik, S. I. Aslam, S. Mehmood, A. Amjad, S. Malik, K. A. Younis, M. Shah, A. H. & Shah, G.M. (2018), “Medicinal plants are effective inhibitors of type I and II diabetes”, Pharmacophore, 9(5), 1-7.

AL-Asiri, I. Sulaiman, H. Alotaibi, F. Predictors of Depression among Diabetes Mellitus Outpatient Attending King Abdul-Aziz Specialist Hospital in Taif, Saudi Arabia (2018). International Journal of Pharmaceutical Research & Allied Sciences, 2018, 7(4):97-103.

Najafipour, M. Bani Mohammad, M. Zareizadeh, M. & Najafipour, F. (2018).“Step by step in management of type 2 diabetes”, International Journal of Pharmaceutical and Phytopharmacological Research, 8(5), pp.68-71.

Dedov I.I., Melnichenko of G.A. Endokrinologiya: national leaders. M.: GEOTAR-media. 2008; 1072 pages [Dedov I.I., Mel'nichenko G.A. Endokrinologiya: natsion-al'noye rukovodstvo. M.: GEOTAR-Media. 2008; 1072 p. (In Russ.)].

Karvonen M., Viik-Kajander M., Moltchanova E., Libman I., LaPorte R., Tuomilehto J. Inci-dence of childhood Type 1 diabetes Worldwide. Diabetes Care, 2000. Oct; 23(10): 1516-1526.

Balabolkin M.I., Klebanova E.M., Kreminskaya V.M. Differential diagnosis and treatment of endocrine diseases: Management. M.: Medicine. 2002; 752 pages [Balabolkin M.I., Klebanova Ye.M., Kreminskaya V.M. Differentsial'naya diagnostika i lecheniye en-dokrinnykh zabolevaniy: Rukovodstvo. M.: Meditsina. 2002; 752 p. (In Russ.)].

King H., Aubert R.E., Herman W.H. Global burden of diabetes, 1995-2025: prevalence, numerical estimates, and projections. Diabetes Care, 1998; 21(9): 1414-1431.

Suntsov Yu.I., Bolotskaya L.L., Maslova O.V., Kazakov I.V. Epidemiology of diabetes and the forecast of its prevalence in the Russian Federation. Diabetes. 2011; 1: 15-18. [Suntsov Yu.I., Bolotskaya L.L., Maslova O.V., Kazakov I.V. Epidemiology of diabetes mellitus and prognosis of its prevalence in the Russian Federation. Diabetes Care. 2011; 1: 15-18. (In Russ.)].

Craig M.E., Hattersley A., Donaghue K.C. Definition epidemiology and classification of dia-betes in children and adolescents. Pediatric Diabetes, 2009; 10 (Suppl. 12): 3-12.

Bykov I.M., Ivchenko L.G., Domenyuk D.A., Kostyukova N.Yu., Storozhuk A.P., Ilidzhev D.M. Uroven of pro-inflammatory salivary at children with autoimmune diabetes in various phases of compensation of an endocrinopathy. Kuban scientific medical bulletin. 2017; 24(4): 39-48. DOI:10.25207/1608-6228-2017-24-4-39-48. [Bykov I.M., Ivchenko L.G., Domenyuk D.A., Kostyukova N.Y., Storozhuk A.P., Ilijev D.M. Salivary the level of proinflammatory cytokines in children with autoimmune diabetes mellitus in different phases of compensation endocrinopathy. Kuban Scientific Medical Bulletin. 2017; 24(4): 39-48. (In Russ., English abstract). DOI: 10.25207/1608-6228-2017-24-4-39-48.

Davydov B.N., Gilmiyarova F.N., Domenyuk D.A., Ivchenko L.G. Kliniko-diagnostichesky value of activity of matriksny metalproteinases and their fabric inhibitors in assessment of a condition of fabrics of the parodont at children with diabetes of the first type. Part I. Stomatology of children's age and prevention. 2017; Volume XVI; 4(63): 14-19. [Davydov B.N., Gilmiyarova F.N., Domenyuk D.A., Ivchenko L.G. Clinical and diagnostic significance of the activity of matrix metalloproteinase and their tissue inhibitors in assessing the condition of periodontal tissues in children with type 1 diabetes mellitus. Part I. Children's dentistry and prevention. 2017; Vol. XVI; 4 (63): 14-19. (In Russ.)].

Dedov I.I., Melnichenko G.A., Fadeyev of V.V. Endokrinologiya: Textbook. M.: Medicine. 2000; 632 pages [Dedov I.I., Mel'nichenko G.A., Fadeyev V.V. Endokrinologiya: Uchebnik. M.: Meditsina. 2000; 632 p. (In Russ.)].

Aguilar-Bryan L., Bryan J. Neonatal diabetes Mellitus. Endocr. Rev., 2008; 29(3): 265-291.

Dedov I.I., Kurayev T.K., Peterkova V. A. Diabetes at children and teenagers: Management. M.: GEOTAR-media. 2013; 272 pages [Dedov I.I., Kurayev T.K., Peterkova V.A. Sakharnyy diabet u detey i podrostkov: Rukovodstvo. M.: GEOTAR-Media. 2013; 272 p. (In Russ.)].

Polak M., Shield J. Neonatal and very-early-onset diabetes mellitus. Semin Neonatol., 2004; Vol. 9: 59–65.

Adlercreutz E.H., Wingren C.J., Vincente R.P. Perinatal risk factors increase the risk of being affected by both type 1 diabetes and coeliac disease. Acta Paediatr. 2015; Vol. 104: 2: 178-184. DOI: 10.1111/apa.12836.

Domenyuk D.A., Davydov B.N., Gilmiyarova F.N., Ivchenko L.G., Vedeshina E.G. Diagnostic and predictive value of crystal structures of oral liquid at children with anomalies of occlusion. Stomatology of children's age and prevention. 2017; Volume XXI; 2(61): 9-16. [Domenyuk D.A., Davydov B.N., Gilmiyarova F.N., Ivchenko L.G., Vedeshina E.G. Diagnostic and prognostic value of crystalline structures of the oral fluid in children with anomalies of occlusion. Children's dentistry and prevention. 2017; Volume XXI; 2(61): 9-16. (In Russ.)].

Gilmiyarova F.N., Davydov B.N., Domenyuk D.A., Ivchenko L.G. Influence of weight of a course of diabetes of the I type at children on the dental status and immunological, biochemical indicators of serum of blood and oral liquid. Part I. Parodontologiya. 2017; Volume XXII; 2(83): 53-60. [Gilmiyarova F.N., Davydov B.N., Domenyuk D.A., Ivchenko L.G. Influence of severity of type I diabetes mellitus in children on dental status and immunological, biochemical parameters of blood serum and oral fluid. Part I. Periodontology. 2017; Vol. XXII; 2 (83): 53-60. (In Russ.)].

Ivchenko L.G., Domenyuk D.A. Diagnostics of immunometabolic frustration at children with diabetes of the I type. Kuban scientific medical bulletin. 2017; 1(2): 73-82. DOI:10.25207/1608-6228-2017-2-73-82. [Ivchenko L.G., Domenyuk D.A. Diagnosis of immunometabolic disorders in children with type 1 diabetes mellitus. Kuban Scientific Medical Bulletin. 2017; 1(2): 73-82. (In Russ., English abstract). DOI:10.25207/1608-6228-2017-2-73-82.

Domenyuk D.A., Vedeshina E.G., Dmitriyenko S.V., Kalashnikova S.A. Quality and quantitative standard of a crystallography of oral liquid is normal and at zubochelyust-ache pathologies. Kuban scientific medical bulletin. 2016; (5): 38-47. DOI:10.25207/1608-6228-2016-5-38-47. [Domenyuk D.A., Vedeshina E.G., Dmitrienko S.V., Kalashnikova S.A. Qualitative and quantitative crystallographic evaluation of oral liquid under normal conditions and in dentofacial pathology. Kuban Scientific Medical Bulletin. 2016; (5): 38-47. (In Russ., English abstract). DOI:10.25207/1608-6228-2016-5-38-47.

Gilmiyarova F.N., Davydov B.N., Domenyuk D.A., Ivchenko L.G. Influence of weight of a course of diabetes of the I type at children on the dental status and immunological, biochemical indicators of serum of blood and oral liquid. Part II. Parodontologiya. 2017; Volume XXII; 3(84): 36-41. [Gilmiyarova F.N., Davydov B.N., Domenyuk D.A., Ivchenko L.G. Influence of severity of type I diabetes mellitus in children on dental status and immunological, biochemical parameters of blood serum and oral fluid. Part II. Periodontology. 2017; Vol. XXII; 3 (84): 36-41. (In Russ.)].

Eubanks D. L. The basics of saliva. J. Vet. Dent., 2010; Vol. 27; 4: 266-267.

Domenyuk D.A., F.N. Gilmiyarova, N.I. Bykova. Metabolic and microbiological features of biotopes of an oral cavity at children with tooth treatment pathology. Stavropol: SMU, 2017. 312 pages

Malamud D. Saliva as a diagnostic fluid. Dental Clin. North Am., 2011; Vol. 55; 1: 159-178.

Domenyuk D.A., Karsliyeva A.G., I.M. Bulls, Kochkonyan A.S. Otsenka of a cariogenic situation at children with tooth treatment anomalies on microbiological and biophysical indicators of oral liquid. Kuban scientific medical bulletin. 2014; (5): 36-46. DOI:10.25207/1608-6228-2014-5-36-46. [Domenyuk D.A., Karslieva A.G., Bykov I.M., Kochkonyan A.S. Evaluation of cariogenic situation in children with dentoalveolar anomalies based on microbiological and biophysical indicators in oral liquid. Kuban Scientific Medical Bulletin. 2014; (5): 36-46. (In Russ., English abstract). DOI:10.25207/1608-6228-2014-5-36-46.

Domenyuk D.A., Davydov B.N., Vedeshina E.G., Dmitriyenko S.V. Improvement of methods of diagnostics of zubochelyustny anomalies by results of studying of functional shifts in the system of an oral homeostasis (Part I). Institute of stomatology. 2016; 71(2): 74-77. [Domenyuk D.A., Davydov B.N., Vedeshina E.G., Dmitrienko S.V. Perfection of diagnostic methods of dentoalveolar anomalies by results of studying functional shifts in the system of oral homeostasis (Part I). The Dental Institute. 2016; 71(2): 74-77. (In Russ.)].

Rabinovich O.F., Abramova E.S. Bactericidal activity of oral liquid in complex diagnostics of disbiotic changes of a mucous membrane of a mouth. Stomatology. 2012; 91(3): 35-37. [Rabinovich O.F., Abramova E.S. Bactericidal activity of oral fluid in complex diagnostics of dysbiotic changes in the oral mucosa. Stomatology. 2012; 91 (3): 35-37. (In Russ.)].

Nieuw Amerongen A.V., Bolscher J.G.M., Veerman E.C.I. Salivary proteins: protective and diagnostic value in cariology. Caries Research. 2004; 38: 247-253.

Davydov B.N., Gilmiyarova F.N., Domenyuk D.A., Ivchenko L.G. clinical-diagnostic value of activity of metal-proteinases and their fabric inhibitors in assessment of a condition of fabrics of the parodont at children with diabetes of the first type. Part II. Stomatology of children's age and prevention. 2018; Volume XVII; 1(64): 37-46. [Davydov B.N., Gilmiyarova F.N., Domenyuk D.A., Ivchenko L.G. Clinical and diagnostic significance of the activity of matrix metalloproteinase and their tissue inhibitors in assessing the condition of periodontal tissues in children with type 1 diabetes mellitus. Part II. Children's dentistry and prevention. 2018; Vol. XVII; 1 (64): 37-46. (In Russ.)].

Nieuw Amerongen A.V., Veerman E.C.I. Saliva the defender or oral cavity. Oral Dis. 2002; 8: 12-22.

Redinova T.L., Ivanova L.A., Martyusheva O.V. Microbiological and clinical characteristics of a disbiotic state in an oral cavity. Stomatology. 2009; 6: 12-18. [Redinova T.L., Ivanova L.A., Martyusheva O.V. Microbiological and clinical character-istics of the dysbiotic state in the oral cavity. Stomatology. 2009; 6: 12-18. (In Russ.)].

Tarasenko L.M., Sukhanova G.A., Mishchenko V. P., Neporada K.S. Salivary glands (biochemistry, physiology, clinical aspects). Tomsk: NTL publishing house, 2002. 124 pages [Tarasenko L.M., Sukhanova G.A., Mischenko V.P., Neporada K.S. Salivary glands (biochemistry, phys-iology, clinical aspects). Tomsk: Publishing house of NTL, 2002. 124 rubles (In Russ.)].

Santos M.T., Batista R. Salivary osmolality and hydration status in children with cerebral palsy. J. Oral. Pathol. Med. 2011; 40 (7): 582-586.




URN: http://nbn-resolving.de/urn:nbn:de:0000easl.v5i4.2824

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<Entomology+Zoology+Allied Branches>Entomology and Applied Science Letters