Entomology and
Applied Science Letters
Submission
Home About Contact Editorial Team Indexing Focus and Scope Submission Guidelines
Archive Current Issue
Creative Commons License 2018 Volume 5 Issue 4

5% Suspension of Albendazole Echinacea Magenta (Echinacea Pur-purea) Toxicometric Evaluation

Lopteva Maria Sergeevna, Kolesnikov Vladimir Ivanovich, Pushkin Sergey Viktorovich, Povetkin Sergey Nikolaevich, Marinicheva Marina Petrovna, Strogov Vladimir Viktorovich, Nagdalian Andrey Ashotovich
Abstract

The acute toxicity of 5% suspension of albendazole Echinacea Magenta (Echinaceapurpurea) was studied when administered orally to outbred white mice. To determine the characteristics of the suspension acute toxicity, it was administered to animals once with varying doses. The general condition and behavior of animals were observed during 14 days. The intoxication symptoms’ manifestation and possible death were noticed. The animals' death was observed within five days after the drug administration. The drug's acute toxicity characteristics were as follows: MPD -740 mg/kg of body weight, and LD50 – 2960 mg/kg of body weight, LD16 -1450,4 mg/kg, LD84– 6050 mg/ kg of body weight. In accordance with Russian State Standard 12.1.007-76, the drug belonged to the class 3 of danger (moderately toxic substance).

Share:
References

Kireev I.V. V.A. Orobets. N.E. Bauman. Acute toxicity of a new antioxidant preparation "Polyoxidol. Uchenye zapiski Kazan State Academy of Veterinary Medicine. 2017. -T. 230. №2. P. 124-127.

Miroshnikova A.I. I.V. Kireev, V.Arobets, V.A. Belyaev, E.V. Rakovskaya. Acute toxicity of a new disinfectant based on silver nanoparticles. Herald of the Agroindustrial Complex of Stavropol. 2014. No2 (14). FROM. 124-127.

Ivette María Menéndez-Perdomo, Ángel Sánchez-Lamar (2017), “Phyllanthus plants in photoprotection: a broad spectrum of molecu-lar mechanisms”. Pharmacophore, 8(3), 1-10.

Mohammad Akram Randhawa, Abdulhakim Bawadekji, Mouhanad Al Ali, Mohamed Habib Oueslati, Jamith Basha W. (2018). “Antimi-crobial Effects of Methanolic Extract of Salvia Officinalis L, Including MRSA and Multidrug Resistant Acinetobacter Baumannii”, Interna-tional Journal of Pharmaceutical and Phyto-pharmacological Research, 8(4), pp.1-5.

Antipov V.A. A.Kh. Shantyz. Study of the toxicity of monclavite. Veterinary Physician. 2008. №2. P. 7-9.

Vasiliev V.F. Shantiz A.H., S.S. Hathakumov. Study of parameters of acute and chronic toxicity of probiotic STF-1/56 TIM. Proceedings of the Kuban State Agrarian University. 2013. No. 45. Pp.169-171.

Kolesnikov V.I. Stepanova, V.V. Bernikovsky, V.I. Chetvertnov, M.S. Saluscheva, RA Starikov. Efficacy of new medicinal forms of albendazole in helminthiasis of sheep. Sheep, goats, woolen business. 2007.№ 3. Pp.60-62.

Kolesnikov V.I. R.A. Starikov, V.I. Chetvertnov, M.S. Saluscheva. Research and efficacy of new drugs in helminthiasis of sheep. Veterinary pathology.2008. №4. pp.127-129.

S. Povetkin. Selyaninov, N.R. Gologrudnikova-Verstyuk, A.N. Simonov, A.V. Egunova. Study of parameters of acute toxicity of acidic fraction of electrochemically activated water against the background of low-intensity laser radiation in relation to lipid peroxidation; In the collection: Actual problems of modern veterinary science and practice materials of the International Scientific and Practical Conference dedicated to the 70th anniversary of the Krasnodar Scientific Research Veterinary Institute. FGBICU "Krasnodar Scientific Research Veterinary Institute". The Kuban State Agrarian University. 2016. FROM. 76-79.

Shantyz A.Kh. Del'tsov ,AA. Estimation of acute toxicity of the preparation Hydropeptone-plus; In the collection: Actual problems of modern veterinary science and practice. Materials of the International Scientific and Practical Conference dedicated to the 70th anniversary of the Krasnodar Scientific Research Veterinary Institute. 2016. FROM. 137-140.

State Standard of the USSR. Occupational safety standards system. Harmful substances. Classification and general safety requirements. GOST 12.1.007-76. M., 1984. 4 p.

V.I. Kolesnikov, R.A. Starikov, V.I. Chetvertnov, M.S. Saluscheva. Efficacy of new preparations of albendazole in helminthiasis of sheep. Herald of veterinary medicine.2008. №2 (45). pp. 34-37.

Kolesnikov V.I. E.F. Stepanova, M.S. Lopteva, V.V. Bernikovsky, V.I. Chetvertnov, RA Starikov. Anthelminthic preparation for the treatment of small cattle. Patent for the invention-RU 2375057-21.01.2008.

European Convention for the Protection of Animals Vertebrate Animals for Experimental and Other Scientific Purposes (ETS 123). Strasbourg, 1986.

Belenky, M.L. Elements of a quantitative assessment of the pharmacological effect. Medicine.1963. 262 p.

Belenky M.P. The basic methods of statistical processing of the results of observations in the field of physiology. Medicine,1963. 126 p.

Entomology and Applied Science Letters is an international double-blind peer reviewed publication which publishes scientific research & review articles related to insects that contain information of interest to a wider audience, e.g. papers bearing on the theoretical, genetic, agricultural, medical and biodiversity issues. Emphasis is also placed on the selection of comprehensive, revisionary or integrated systematics studies of broader biological or zoogeographical relevance. In addition to full-length research articles and reviews, the journal publishes interpretive articles in a Forum section, Short Communications, and Letters to the Editor. The journal publishes reports on all phases of medical entomology and medical acarology, including the systematics and biology of insects, acarines, and other arthropods of public health and veterinary significance.

Announcement and Advertisement
Announcements regarding scientific activities such as conferences, symposium, are published for free. Advertisements can be either published or placed on website as banners.

Publisher
Institute of Pharmaceutical Sciences (IPS) , University of Veterinary and Animal Sciences, Lahore Pakistan.
open access
Associations
Entomology and Applied Science Letters supports the submission of entomological papers that contain information of interest to a wider reader groups e. g. papers bearing on taxonomy, phylogeny, biodiversity, ecology, systematic, agriculture, morphology. The selection of comprehensive, revisionary or integrated systematics studies of broader biological or zoogeographical relevance is also important. Distinguished entomologists drawn from different parts of the world serve as honorary members of the Editorial Board. The journal encompasses all the varied aspects of entomological research.