Creative Commons License 2019 Volume 6 Issue 3

Antinociceptive Effects and Acute Toxicity of Nectaroscordum koelzi ex-tract ‎in Mice


Mojtaba Khaksarian, Eskandar Hamidikia, Maryam Sepahvand, Behrooz Farzan
Abstract

The objective of this study was to assess the antinociceptive activity and acute toxicity of Nectaroscordum koelzi fruit extract in mice. Totally, 90 BALB/c mice were used to determine the antinociceptive effect of the extract using rotarod, tail-flick, and hot plate tests. The acute toxicity was determined at doses of 1, 2, 4, 6 g/kg for 2 days. The maximum non-fatal dose and the LD50 value of N. koelzi fruit extract were 1.97 g/kg and 2.91 g/kg, respectively. The findings showed that in tail-flick and hot plate tests, 250, 500, and 750 mg/kg of N. koelzi fruit extract had a dose-dependent analgesic effect, 30min after administration and a significant difference was observed between the groups receiving the extract and saline (p<0.05). Moreover, the results showed no significant (p>0.05) changes with injecting the above-mentioned doses of N. koelzi fruit extract in sensory-motor test. The findings revealed the potent antinociceptive activity of N. koelzi fruit extract in mice. However, the exact mechanisms, which are responsible for the pharmacological effects have not been investigated, yet.


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Entomology and Applied Science Letters is an international double-blind peer reviewed publication which publishes scientific research & review articles related to insects that contain information of interest to a wider audience, e.g. papers bearing on the theoretical, genetic, agricultural, medical and biodiversity issues. Emphasis is also placed on the selection of comprehensive, revisionary or integrated systematics studies of broader biological or zoogeographical relevance. In addition to full-length research articles and reviews, the journal publishes interpretive articles in a Forum section, Short Communications, and Letters to the Editor. The journal publishes reports on all phases of medical entomology and medical acarology, including the systematics and biology of insects, acarines, and other arthropods of public health and veterinary significance.

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