Antinociceptive Effects and Acute Toxicity of Nectaroscordum koelzi ex-tract ‎in Mice

The objective of this study was to assess the antinociceptive activity and acute toxicity of Nectaroscordum koelzi fruit extract in mice. Totally, 90 BALB/c mice were used to determine the antinociceptive effect of the extract using rotarod, tail-flick, and hot plate tests. The acute toxicity was determined at doses of 1, 2, 4, 6 g/kg for 2 days. The maximum non-fatal dose and the LD₅₀ value of N. koelzi fruit extract were 1.97 g/kg and 2.91 g/kg, respectively. The findings showed that in tail-flick and hot plate tests, 250, 500, and 750 mg/kg of N. koelzi fruit extract had a dose-dependent analgesic effect, 30min after administration and a significant difference was observed between the groups receiving the extract and saline (p<0.05). Moreover, the results showed no significant (p>0.05) changes with injecting the above-mentioned doses of N. koelzi fruit extract in sensory-motor test. The findings revealed the potent antinociceptive activity of N. koelzi fruit extract in mice. However, the exact mechanisms, which are responsible for the pharmacological effects have not been investigated, yet‎.

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