Creative Commons License 2016 Volume 3 Issue 4

P2O5/Al2O3: An efficient and Reusable Catalyst for the Synthesis of Trisubstituted Imidazoles under solvent- free conditions

Mona Esmaeilzadeh, Sadegh Allameh, Hossein Behmadi

An efficient and simple one-pot multicomponent procedure for the synthesis of imidazoles from the condensation of benzyl, ammonium acetate and aromatic aldehydes in the presence of a catalytic amount of alumina-supported phosphorus pentoxide /Al2O3 (P2O5/Al2O3) under solvent- free conditions is reported.


Keywords: Imidazoles, P2O5/Al2O3, Solvent- free conditions, Reusable catalyst;


M. H. Alizadeh, H. Razavi, F.F. Bamoharram. J. Mol. Cat., 2003; 206, 89.

J. Zhu, H. Bienayme, H. Multicomponent Reactions. Wiley-VCH: Weinheim, 2005.

V. P. Litvinov, Russ. Chem. Rev., 2003; 72, 69.

I. Ugi, A. Domling, W. Horl. Endeavour. 1994; 18, 115.

L. F. Tietze, A. Modi, Med. Res. Rev., 2000; 20, 304.

I. Ugi, A. Dömling, B. Werner, J. Heterocycl. Chem. 2000; 37, 647.

S. A. Laufer, W. Zimmermann, K. J. Ruff, J. Med. Chem., 2004; 47, 6311.

S. E. Wolkenberg, D. D. Wisnoski, W. H. Leister, Y. Wang, Org. Lett., 2004; 6, 1453.

J. G. Lombardino, E. H. Wiseman, J. Med. Chem., 1974; 17, 1182.

S. Samai, G. C. Nandi, P. Singh, M.S. Singh, Tetrahedron. 2009; 65.

G. V. M. Sharma, Y. Jyothi, P. S. Lakshmi, Synth. Commun. 2006; 36.

S. D. Sharma, P. Hazarika, D. Konwar, Tetrahedron Lett. 2008; 49.

S. Kantevari, S. V. N. Vuppalapati, D. O. Biradar, L. Nagarapu, J. Mol. Catal. 2007; 266.

B. Sadeghi, B.B.F. Mirjalili, M.M. Hashemi, Tetrahedron Lett, 2008; 49.

M. M. Heravi, F. Derikvand, F. F. Bamoharram, J. Mol. Catal., 2007; 263.

L. M. Wang, Y. H. Wang, H. Tian, J. Fluor. Chem., 2006; 127.

A. Hasaninejad, A. Zare, M. Shekouhy, J. Ameiri Rad, J. Comb. Chem, 2010; 12.

M. M. Heravi, K. Bakhtiari, H. A. Oskooie, S. Taheri, J. Mol. Catal., 2007; 263.

S. Allameh, M. M. Heravi, M. M. Hashemi, F. Bamoharram, Chines Chemical Letters. 2011; 22, 131.

A. Davoodnia, S. Allameh, S. Fazli, N. Tavakoli- Hoseini, Chemical papers., 2011; 65, 5.

G. Yasaghi, A. Davoodnia, S. Allameh, A. Zare- Bidaki, N. Tavakoli- Hoseini, Bull. Korean Chem Soc., 2012; 33, 8.

M. Roshani, S. Allameh, E. Darkooti, Asian Journal of Chemistry, 2013; 125, 4.

M. Ashrafi, A. Davoodnia, N. Tavakoli- Hoseini, Bull. Korean Chem Soc., 2013; 34, 5.

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