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Creative Commons License 2016 Volume 3 Issue 5

Anti-inflammatory and antinociceptive effects of Dolichandrone Falcata fruit extracts in animal models

Badgujar Vishal Bhagwan, Surana Sanjay J, Badgujar Sangita V
Abstract

Despite traditional claims about the pharmacological properties of Dolichandrone falcata and the successful isolation of bioactive compounds from its leaves, no in-depth scientific study has been carried out on their effects. The present study was carried out to determine the anti-inflammatory and antinociceptive activities of the methanol (DFFM) and ethyl acetate (DFFEA) extracts of Dolichandrone falcata fruits using animal models. An extract was obtained from air-dried, powdered fruits (900 g) using a Soxhlet extractor with methanol, it was then treated to obtain the ethyl acetate extract. The crude dried DFFM extract (90 g) and DFFEA extract (18 g) were used to prepare formulations, at doses of 100, 200 and 400 mg/kg, that were used in anti-inflammatory (carrageenan- and histamine-induced paw edema test) and antinociceptive (abdominal constriction, hot plate and tail flick tests) assays. The results obtained indicate that the extracts exhibited significant (P< 0.001) anti-inflammatory and antinociceptive effects, which were found to be dose dependent. The highest doses of both extracts were most significant and effective. This study showed that the methanol and ethyl acetate extracts of Dolichandronefalcata fruits possess potentially pharmacologically active constituents responsible for inhibition of inflammation and nociceptive effects.

 

Key Words: Bignoniaceae, Dolichandrone falcata, Anti-inflammatory, Antinociceptive

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Entomology and Applied Science Letters is an international double-blind peer reviewed publication which publishes scientific research & review articles related to insects that contain information of interest to a wider audience, e.g. papers bearing on the theoretical, genetic, agricultural, medical and biodiversity issues. Emphasis is also placed on the selection of comprehensive, revisionary or integrated systematics studies of broader biological or zoogeographical relevance. In addition to full-length research articles and reviews, the journal publishes interpretive articles in a Forum section, Short Communications, and Letters to the Editor. The journal publishes reports on all phases of medical entomology and medical acarology, including the systematics and biology of insects, acarines, and other arthropods of public health and veterinary significance.

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Entomology and Applied Science Letters supports the submission of entomological papers that contain information of interest to a wider reader groups e. g. papers bearing on taxonomy, phylogeny, biodiversity, ecology, systematic, agriculture, morphology. The selection of comprehensive, revisionary or integrated systematics studies of broader biological or zoogeographical relevance is also important. Distinguished entomologists drawn from different parts of the world serve as honorary members of the Editorial Board. The journal encompasses all the varied aspects of entomological research.