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Creative Commons License 2018 Volume 5 Issue 4

Some Functional Measures of the Organism of Rats at Modeling of Ischemic Heart Disease in Two Different Ways

Areshidze D. A., Mischenko D. V., Makartseva L. A., Kucher S. A., Kozlova M. A., Timchenko L. D., Rzhepakovsky I. V., Nagdalian A. A., Pushkin S. V.
Abstract

The study was conducted to examine the influence of two methods of modeling of ischemic heart disease on the amount of ischemic fibers in the myocardium parameters, characterizing the cardiovascular system, the coagulation properties of blood, and its electrolyte composition. It was shown that at modeling of IHD by introducing doxorubicin, several functional changes occurred, but the nature of the changes of the studied parameters evidenced a predominantly cardiotoxic effect of doxorubicin, which did not lead to the morphological picture characteristic of IHD. At modeling of ischemic heart disease by co-administering adrenaline and hydrocortisone, morphofunctional disorders were manifested in significant pathological changes in the myocardium of rats, and this method can be used as a model to identify the therapeutic efficacy of potential drugs aimed at preventing and treating the ischemic heart disease.

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Entomology and Applied Science Letters is an international double-blind peer reviewed publication which publishes scientific research & review articles related to insects that contain information of interest to a wider audience, e.g. papers bearing on the theoretical, genetic, agricultural, medical and biodiversity issues. Emphasis is also placed on the selection of comprehensive, revisionary or integrated systematics studies of broader biological or zoogeographical relevance. In addition to full-length research articles and reviews, the journal publishes interpretive articles in a Forum section, Short Communications, and Letters to the Editor. The journal publishes reports on all phases of medical entomology and medical acarology, including the systematics and biology of insects, acarines, and other arthropods of public health and veterinary significance.

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Entomology and Applied Science Letters supports the submission of entomological papers that contain information of interest to a wider reader groups e. g. papers bearing on taxonomy, phylogeny, biodiversity, ecology, systematic, agriculture, morphology. The selection of comprehensive, revisionary or integrated systematics studies of broader biological or zoogeographical relevance is also important. Distinguished entomologists drawn from different parts of the world serve as honorary members of the Editorial Board. The journal encompasses all the varied aspects of entomological research.