Creative Commons License 2019 Volume 6 Issue 2

Hepatoprotective Effects of Capparis spinosa L. Fruit Extract in Mice‎ ‎

Sareh Jahanbakhsh, Mehrdad Khatami, Massumeh Niazi, Alireza Moayyedkazemi

Objective: The aim of this study is to evaluate the hepatoprotective effect of methanolic and aqueous extract of Capparis spinosa L. fruit in mice. Methods: The hepatoprotective effects of methanolic extract of C. spinosa was assessed by measuring the serum levels of enzymes including bilirubin, alkaline phosphatase (ALP), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) in the treated mice after oral administration of C. spinosa at the doses of 250, 500, and 750 µg/kg, respectively, for 14 days. Results: The results demonstrated that C. spinosa at the tested doses of 250, 500, and 750 mg/kg had no significant toxicity on the serum liver enzymes of ALT, AST, ALP, and bilirubin. Conclusion: The findings revealed the hepatoprotective effects of methanolic extract of C. spinosa in mice.


World Health Organization. General guidelines for methodologies on research and ‎evaluation of traditional medicine. Geneva: World Health Organization; 2000.‎

Garodia P, Ichikawa H, Malani N, Sethi G, Aggarwal BB. From ancient medicine to modern ‎medicine: ayurvedic concepts of health and their role in inflammation and cancer. J Soc ‎Integr Oncol. 2007 Mar 21;5(1):25-37.‎

Tilburt JC, Kaptchuk TJ. Herbal medicine research and global health: an ethical analysis. ‎Bulletin of the World Health Organization. 2008;86:594-9. ‎

Giannini EG, Testa R, Savarino V. Liver enzyme alteration: a guide for clinicians. Cmaj. ‎‎2005 Feb 1;172(3):367-79.‎

Mahmoudvand H, Fallahi S, Mahmoudvand H, Shakibaie M, Harandi MF, Dezaki ES. ‎Efficacy of Myrtus communis L. to inactivate the hydatid cyst protoscoleces. Journal of ‎Investigative Surgery. 2016 May 3;29(3):137-43.‎

Fallahi S, Beyranvand M, Mahmoudvand H, Nayebzadeh H, Kheirandish F, Jahanbakhsh S. ‎Chemical composition, acute and sub-acute toxicity of Satureja khuzestanica essential ‎oil in mice. Marmara Pharmaceutical Journal. 2017 Jan 1;21(3):515-21.‎

Mahmoudvand H, Tavakoli Oliaei R, Mirbadie SR, Kheirandish F, Tavakoli Kareshk A, ‎Ezatpour B, Mahmoudvand H. Efficacy and safety of Bunium persicum (Boiss) to ‎inactivate protoscoleces during hydatid cyst operations. Surgical infections. 2016 Dec ‎‎1;17(6):713-9.‎

Mahmoudvand H, Mahmoudvand H, Oliaee RT, Kareshk AT, Mirbadie SR, Aflatoonian ‎MR. In vitro protoscolicidal effects of cinnamomum zeylanicum essential oil and its ‎toxicity in mice. Pharmacognosy magazine. 2017 Oct;13(Suppl 3):S652.‎

Zargari A. Medicinal Plants. Vol.2. Tehran University Publication, Tehran, Iran 1989, pp. ‎‎550.‎

Ghahraman A. Chromophytes of Iran, Vol.1 Tehran University Press, Tehran, Iran 1998, pp. ‎‎202.‎

Ebrahimi K, Shiravand S, Mahmoudvand H. Biosynthesis of copper nanoparticles using ‎aqueous extract of Capparis spinosa fruit and investigation of its antibacterial activity. ‎Marmara Pharmaceutical Journal. 2017 Jan 1;21(4):866-71.‎

Masoumi-Ardakani Y, Mahmoudvand H, Mirzaei A, Esmaeilpour K, Ghazvini H, Khalifeh ‎S, Sepehri G. The effect of Elettaria cardamomum extract on anxiety-like behavior in a ‎rat model of post-traumatic stress disorder. Biomedicine & Pharmacotherapy. 2017 Mar ‎‎1;87:489-95.‎

Mahmoudvand H, Asadi A, Harandi MF, Sharififar F, Jahanbakhsh S, Dezaki ES. In vitro ‎lethal effects of various extracts of Nigella sativa seed on hydatid cyst protoscoleces. ‎Iranian journal of basic medical sciences. 2014 Dec;17(12):1001-6.‎

Mahmoudvand H, Dezaki ES, Sharififar F, Ezatpour B, Jahanbakhsh S, Harandi MF. ‎Protoscolecidal effect of Berberis vulgaris root extract and its main compound, ‎berberine in cystic echinococcosis. Iranian journal of parasitology. 2014 Oct;9(4):503-‎‎10‎

Mahmoudvand H, Sepahvand P, Jahanbakhsh S, Azadpour M. Evaluation of the ‎antileishmanial and cytotoxic effects of various extracts of garlic (Allium sativum) on ‎Leishmania tropica. Journal of Parasitic Diseases. 2016 Jun 1;40(2):423-6.‎

Saedi Dezaki E, Mahmoudvand H, Sharififar F, Fallahi S, Monzote L, Ezatkhah F. ‎Chemical composition along with anti-leishmanial and cytotoxic activity of Zataria ‎multiflora. Pharmaceutical biology. 2016 May 3;54(5):752-8.‎

Jahanbakhsh S, Azadpour M, Kareshk AT, Keyhani A, Mahmoudvand H. Zataria multiflora ‎Bioss: lethal effects of methanolic extract against protoscoleces of Echinococcus ‎granulosus. Journal of parasitic diseases. 2016 Dec 1;40(4):1289-92.‎

Mahmoudvand H, Kheirandish F, Dezaki ES, Shamsaddini S, Harandi MF. Chemical ‎composition, efficacy and safety of Pistacia vera (var. Fandoghi) to inactivate ‎protoscoleces during hydatid cyst surgery. Biomedicine & Pharmacotherapy. 2016 Aug ‎‎1;82:393-8.‎

World Health Organization. National policy on traditional medicine and regulation of ‎herbal medicines: Report of a WHO global survey.‎

Ekor M. The growing use of herbal medicines: issues relating to adverse reactions and ‎challenges in monitoring safety. Frontiers in pharmacology. 2014 Jan 10;4:177.‎

Godipurge SS, Biradar NJ, Biradar JS, Mahurkar N. Chemical composition and ‎hepatoprotective effects of polyphenolic fraction from Rivea hypocrateriformis in ‎paracetamol induced liver damage in wistar albino rats. Int J Pharm Pharm Sci ‎‎2016;8(10):228-34.‎

Bateman J, Chapman RD, Simpson D. Possible toxicity of herbal remedies. Scottish ‎Medical Journal. 1998 Feb;43(1):7-15.‎

Ingawale DK, Shah PV, Patel SS. Hepatoprotective effect of virgoliv syrup against ccl4 induced ‎hepatic injury in rats. 2015. 2015;6‎.

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Entomology and Applied Science Letters supports the submission of entomological papers that contain information of interest to a wider reader groups e. g. papers bearing on taxonomy, phylogeny, biodiversity, ecology, systematic, agriculture, morphology. The selection of comprehensive, revisionary or integrated systematics studies of broader biological or zoogeographical relevance is also important. Distinguished entomologists drawn from different parts of the world serve as honorary members of the Editorial Board. The journal encompasses all the varied aspects of entomological research.