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Creative Commons License 2016 Volume 3 Issue 5

Preliminary Phytochemical Screening, Analgesic and Anti-inflammatory effect of Eryngium pyramidale Boiss. & Husson Essential Oil in Male Rat

Ali Reza Fallahzadeh, Mohammad Zarei, Saeed Mohammadi
Abstract

Objective: Eryngium pyramidale is one of the important medicinal plants that use in iranian folk medicine. In this study, we aimed to assess the Phytochemical Screening, analgesic and anti-inflammatory effects of Eryngium pyramidale essential oil in rats. Materials and methods: The essential oil of Eryngium pyramidale (EOEP) was treatment in doses of 10, 50, and 100 mg/kg. In addition, anti-nociceptive activity of EOEP was evaluated by formalin, writhing, and tail-flick tests. EOEP was also that combined with 2 mg/kg naloxone to determine the involvement of opioid mechanism. Anti-inflammatory reaction was evaluated via xylene-induced ear edema. Also the EOEP origin has been analyzed by a combination of GC and GC/MS. Results: The EOEP at dose of 10-100 mg/kg have been shown significant analgesic effects(p<0.05) in compare of standard opioid agonist drug (morphine) and non-steroidal anti-inflammatory drug (indomethacine). Use of naloxone plus EOEP has been inhibited pain in all three models. The present results shown that anti-inflammatory effect of EOEP in the xylene-induced ear edema test is significant (p<0.05) in compare to dexamethasone. The major components in the tested oils was mainly contained quercetin, Isoquercitrin and luteolin. Conclusion: Our findings propose that EOEP probably have analgesic and anti-inflammatory effects. Existent of flavonoids may be an important reason for mentioned effects.

 

Keywords: Pain, Essential oil, Eryngium pyramidale, Medicinal plants

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