Entomology and
Applied Science Letters
Submission
Home About Contact Editorial Team Indexing Focus and Scope Submission Guidelines
Archive Current Issue
Creative Commons License 2016 Volume 3 Issue 5

Preliminary Phytochemical Screening, Analgesic and Anti-inflammatory effect of Eryngium pyramidale Boiss. & Husson Essential Oil in Male Rat

Ali Reza Fallahzadeh, Mohammad Zarei, Saeed Mohammadi
Abstract

Objective: Eryngium pyramidale is one of the important medicinal plants that use in iranian folk medicine. In this study, we aimed to assess the Phytochemical Screening, analgesic and anti-inflammatory effects of Eryngium pyramidale essential oil in rats. Materials and methods: The essential oil of Eryngium pyramidale (EOEP) was treatment in doses of 10, 50, and 100 mg/kg. In addition, anti-nociceptive activity of EOEP was evaluated by formalin, writhing, and tail-flick tests. EOEP was also that combined with 2 mg/kg naloxone to determine the involvement of opioid mechanism. Anti-inflammatory reaction was evaluated via xylene-induced ear edema. Also the EOEP origin has been analyzed by a combination of GC and GC/MS. Results: The EOEP at dose of 10-100 mg/kg have been shown significant analgesic effects(p<0.05) in compare of standard opioid agonist drug (morphine) and non-steroidal anti-inflammatory drug (indomethacine). Use of naloxone plus EOEP has been inhibited pain in all three models. The present results shown that anti-inflammatory effect of EOEP in the xylene-induced ear edema test is significant (p<0.05) in compare to dexamethasone. The major components in the tested oils was mainly contained quercetin, Isoquercitrin and luteolin. Conclusion: Our findings propose that EOEP probably have analgesic and anti-inflammatory effects. Existent of flavonoids may be an important reason for mentioned effects.

 

Keywords: Pain, Essential oil, Eryngium pyramidale, Medicinal plants

Share:
References

Baker MD, Wood JN. Involvement of Na+ channels in pain pathways. Trends in pharmacological sciences. 2001 Jan;22(1):27-31. PubMed PMID: 11165669.

Moniruzzaman M, Hossain MS, Bhattacharjee PS. Evaluation of antinociceptive activity of methanolic extract of leaves of Stephania japonica Linn. Journal of ethnopharmacology. 2016 Jun 20;186:205-8. PubMed PMID: 27060632.

Strzelecka M, Bzowska M, Koziel J, Szuba B, Dubiel O, Riviera Nunez D, et al. Anti-inflammatory effects of extracts from some traditional Mediterranean diet plants. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 2005 Mar;56 Suppl 1:139-56. PubMed PMID: 15800391.

Gagnier JJ, Oltean H, van Tulder MW, Berman BM, Bombardier C, Robbins CB. Herbal Medicine for Low Back Pain: A Cochrane Review. Spine. 2016 Jan;41(2):116-33. PubMed PMID: 26630428.

Worz A. On the Distribution and Relationships of the South-West Asian Species of Eryngium L. (Apiaceae-Saniculoideae). Turk J Bot. 2004;28:85-92.

Calvino CI, Martinez SG, Downie SR. The evolutionary history of Eryngium (Apiaceae, Saniculoideae): rapid radiations, long distance dispersals, and hybridizations. Molecular phylogenetics and evolution. 2008 Mar;46(3):1129-50. PubMed PMID: 18178486.

Kartal M, Mitaine-Offer AC, Paululat T, Abu-Asaker M, Wagner H, Mirjolet JF, et al. Triterpene saponins from Eryngium campestre. Journal of natural products. 2006 Jul;69(7):1105-8. PubMed PMID: 16872157.

Kartal M, Mitaine-Offer AC, Abu-Asaker M, Miyamoto T, Calis I, Wagner H, et al. Two new triterpene saponins from Eryngium campestre. Chemical & pharmaceutical bulletin. 2005 Oct;53(10):1318-20. PubMed PMID: 16204991.

Baytop T. Therapy with medicinal Plants in Turkey (Past and Present). Nobel Typ. Kitapevleri Press, Istanbul; 2013, 954-959.

Jaghabir M. Hypoglycemic effects of Eryngium creticum. Arch Pharm Res. 1991;14(4):295-7.

Goleniowski ME, Bongiovanni GA, Palacio L, Nunez CO, Cantero JJ. Medicinal plants from the "Sierra de Comechingones", Argentina. Journal of ethnopharmacology. 2006 Oct 11;107(3):324-41. PubMed PMID: 16949228.

Bencao E. Zhonghua Bencao. Shanghai Science and Technology Press: Shanghai; 1999. p. 122-8.

A Zargari. Medicinal Plants. Medicinal Plants. Tehran, University Press 1990, 4:574- 5782015.

Dawilai S, Muangnoi C, Praengamthanachoti P, Tuntipopipat S. Anti-inflammatory activity of bioaccessible fraction from Eryngium foetidum leaves. BioMed research international. 2013;2013:958567. PubMed PMID:

Pubmed Central PMCID: 3789289.

Vale TG, Matos FJ, de Lima TC, Viana GS. Behavioral effects of essential oils from Lippia alba (Mill.) N.E. Brown chemotypes. Journal of ethnopharmacology. 1999 Nov 1;67(2):127-33. PubMed PMID: 10619375.

Carbone L, Austin J. Pain and Laboratory Animals: Publication Practices for Better Data Reproducibility and Better Animal Welfare. PloS one. 2016;11(5):e0155001. PubMed PMID: 27171143. Pubmed Central PMCID: 4865140.

Sparkman OD. Identification of essential oil components by gas chromatography/quadrupole mass spectroscopy Robert P. Adams. Journal of the American Society for Mass Spectrometry. 2005;16(11):1902-3.

Lorke D. A new approach to practical acute toxicity testing. Archives of toxicology. 1983 Dec;54(4):275-87. PubMed PMID: 6667118.

Collier H, Dinneen L, JOHNSON CA, Schneider C. The abdominal constriction response and its suppression by

analgesic drugs in the mouse. British journal of pharmacology and chemotherapy. 1968;32(2):295-310.

D'amour FE, Smith DL. A method for determining loss of pain sensation. Journal of Pharmacology and Experimental Therapeutics. 1941;72(1):74-9.

Dubuisson D, Dennis SG. The formalin test: a quantitative study of the analgesic effects of morphine, meperidine, and brain stem stimulation in rats and cats. Pain. 1978;4:161-74.

Hosseinzadeh H, Ramezani M, Salmani G. Antinociceptive, anti-inflammatory and acute toxicity effects of Zataria multiflora Boiss extracts in mice and rats. Journal of ethnopharmacology. 2000 Dec;73(3):379-85. PubMed PMID: 11090990.

Gawade SP. Acetic acid induced painful endogenous infliction in writhing test on mice. Journal of pharmacology & pharmacotherapeutics. 2012 Oct;3(4):348. PubMed PMID: 23326113. Pubmed Central PMCID: 3543562.

Baeta-Corral R, Defrin R, Pick CG, Gimenez-Llort L. Tail-flick test response in 3xTg-AD mice at early and advanced stages of disease. Neuroscience letters. 2015 Jul 23;600:158-63. PubMed PMID: 26091881.

Abbott FV, Franklin KB, Westbrook RF. The formalin test: scoring properties of the first and second phases of the pain response in rats. Pain. 1995 Jan;60(1):91-102. PubMed PMID: 7715946.

Tjolsen A, Berge OG, Hunskaar S, Rosland JH, Hole K. The formalin test: an evaluation of the method. Pain. 1992 Oct;51(1):5-17. PubMed PMID: 1454405.

Barros I, Lopes L, Borges M, Borges A, Ribeiro M, Freire S. Anti-inflammatory and anti-nociceptive activities of Pluchea quitoc (DC.) ethanolic extract. Journal of ethnopharmacology. 2006;106(3):317-20.

Evans WC. Trease and Evans' pharmacognosy: Elsevier Health Sciences; 2009.

Chen FF, Huo FQ, Xiong H, Wan Q, Zheng YN, Du WJ, et al. Analgesic effect of total flavonoids from Sanguis draxonis on spared nerve injury rat model of neuropathic pain. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2015 Nov 15;22(12):1125-32. PubMed PMID: 26547536.

Higgs J, Wasowski C, Loscalzo LM, Marder M. In vitro binding affinities of a series of flavonoids for muopioid receptors. Antinociceptive effect of the synthetic flavonoid 3,3 dibromoflavanone in mice. Neuropharmacology. 2013 Sep;72:9-19. PubMed PMID: 23624290.

Mohammadi S, Zarei M, Zarei MM, Salehi I. Effect of Hydroalcoholic Leaves Extract of Rhus Coriaria on Pain

in Male Rats. Anesthesiology and pain medicine. 2016;6(1)

Ozek M, Uresin Y, Gungor M. Comparison of the effects of specific and nonspecific inhibition of nitric oxide synthase on morphine analgesia, tolerance and dependence in mice. Life sciences. 2003 Mar 14;72(17):1943-51. PubMed PMID: 12597993

Kaur R, Singh D, Chopra K. Participation of alpha2 receptors in the antinociceptive activity of quercetin. Journal of medicinal food. 2005 Winter;8(4):529-32. PubMed PMID: 16379567.

Martinez-Florez S, Gutierrez-Fernandez B, Sanchez-Campos S, Gonzalez-Gallego J, Tunon MJ. Quercetin attenuates nuclear factor-kappaB activation and nitric oxide production in interleukin-1beta-activated rat hepatocytes. The Journal of nutrition. 2005 Jun;135(6):1359-65. PubMed PMID: 15930438.

Morales AI, Vicente-Sanchez C, Jerkic M, Santiago JM, Sanchez-Gonzalez PD, Perez-Barriocanal F, et al. Effect of quercetin on metallothionein, nitric oxide synthases and cyclooxygenase-2 expression on experimental chronic cadmium nephrotoxicity in rats. Toxicology and applied pharmacology. 2006 Jan 1;210(1-2):128-35. PubMed PMID: 16226777.

de Campos Buzzi F, Franzoi CL, Antonini G, Fracasso M, Cechinel Filho V, Yunes RA, et al. Antinociceptive properties of caffeic acid derivatives in mice. European journal of medicinal chemistry. 2009 Nov;44(11):4596-602. PubMed PMID: 19628311.

Michaluart P, Masferrer JL, Carothers AM, Subbaramaiah K, Zweifel BS, Koboldt C, et al. Inhibitory effects of caffeic acid phenethyl ester on the activity and expression of cyclooxygenase-2 in human oral epithelial cells and in a rat model of inflammation. Cancer research. 1999 May 15;59(10):2347-52. PubMed PMID: 10344742.

Park SH, Sim YB, Kang YJ, Kim SS, Kim CH, Kim SJ, et al. Antinociceptive profiles and mechanisms of orally administered coumarin in mice. Biological & pharmaceutical bulletin. 2013;36(6):925-30. PubMed PMID: 23727914

Entomology and Applied Science Letters is an international double-blind peer reviewed publication which publishes scientific research & review articles related to insects that contain information of interest to a wider audience, e.g. papers bearing on the theoretical, genetic, agricultural, medical and biodiversity issues. Emphasis is also placed on the selection of comprehensive, revisionary or integrated systematics studies of broader biological or zoogeographical relevance. In addition to full-length research articles and reviews, the journal publishes interpretive articles in a Forum section, Short Communications, and Letters to the Editor. The journal publishes reports on all phases of medical entomology and medical acarology, including the systematics and biology of insects, acarines, and other arthropods of public health and veterinary significance.

Announcement and Advertisement
Announcements regarding scientific activities such as conferences, symposium, are published for free. Advertisements can be either published or placed on website as banners.

Publisher
Institute of Pharmaceutical Sciences (IPS) , University of Veterinary and Animal Sciences, Lahore Pakistan.
open access
Associations
Entomology and Applied Science Letters supports the submission of entomological papers that contain information of interest to a wider reader groups e. g. papers bearing on taxonomy, phylogeny, biodiversity, ecology, systematic, agriculture, morphology. The selection of comprehensive, revisionary or integrated systematics studies of broader biological or zoogeographical relevance is also important. Distinguished entomologists drawn from different parts of the world serve as honorary members of the Editorial Board. The journal encompasses all the varied aspects of entomological research.