Sub-acute toxicity of the alien Cassiopea andromeda (forsskal, 1775) jellyfish venom, in rats

Gholamhossein Mohebbi; Parviz Farzadinia; Hossein Vatanpour; Arman Hashemi; Amir Vazirizadeh; Zahra khazaei; Samad Akbarzadeh; Mohammadreza Mirshamsi; Iraj Nabipour

2016 Volume 3 Issue 2

Sub-acute toxicity of the alien Cassiopea andromeda (forsskal, 1775) jellyfish venom, in rats

Gholamhossein Mohebbi, Parviz Farzadinia, Hossein Vatanpour, Arman Hashemi, Amir Vazirizadeh, Zahra khazaei, Samad Akbarzadeh, Mohammadreza Mirshamsi, Iraj Nabipour

Abstract

The sub-acute toxicity of the crude tentacle-only extract from the alien Cassiopea andromeda (forsskal, 1775) jellyfish was studied in rat within 21 days after exposure. For sub-acute toxicity, changes in weights and pathological parameters were studied. The intraperitoneal LD50 value of venom was estimated 104.0 μg/kg BW in male mice. For sub-acute toxicity, 3 doses of crude venom (0.0125, 0.025 and 0.05 μg/ml/day) were administered intraperitoneally to female rats, once daily for 21 days. Increase in size and weights were observed in the spleens in all groups. The Scab-like spots were seen on skin of all the rats. Histopathological examinations of the rat kidney, heart, liver and spleen tissues indicated that there were different demonstrable abnormalities and alterations in the microscopic examinations in comparison to their control groups, especially at a higher dose of 0.05 μg/ml/day.

Key words: Sub-acute toxicity, Cassiopea andromeda jellyfish, Histopathological examinations

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Entomology and Applied Science Letters is an international double-blind peer reviewed publication which publishes scientific research & review articles related to insects that contain information of interest to a wider audience, e.g. papers bearing on the theoretical, genetic, agricultural, medical and biodiversity issues. Emphasis is also placed on the selection of comprehensive, revisionary or integrated systematics studies of broader biological or zoogeographical relevance. In addition to full-length research articles and reviews, the journal publishes interpretive articles in a Forum section, Short Communications, and Letters to the Editor. The journal publishes reports on all phases of medical entomology and medical acarology, including the systematics and biology of insects, acarines, and other arthropods of public health and veterinary significance.

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