Creative Commons License 2019 Volume 6 Issue 1

A Review of Medicinal Herbs in the Lamiaceae Family Used to Treat Arterial Hypertension

Massumeh Niazi, Fatemeh Yari, Amir Shakarami

Today, high blood pressure (arterial hypertension) is one of the most common cardiovascular diseases all over the world, particularly in developing countries. The Lamiaceae family is considered as one of the most important herbal families that have many plants with various pharmacological and therapeutic use around the world. This study aims to review medicinal herbs in the Lamiaceae family used to treat hypertension around the world. The obtained results of the present review investigation demonstrated that 26 medicinal herbs were traditionally used to treat hypertension around the world. The most important parts of these plants are leaves, roots, and flowers, respectively; whereas these medicinal herbs are most commonly used in Asian and African countries such as Iran, Pakistan, India, South Africa, etc. The results demonstrated that medicinal herbs in Lamiaceae family have universally used to treat hypertension. Thus, we can consider them as alternative agents for treatment of hypertension; nevertheless, more investigations are mandatory to elucidate the precise anti-hypertensive mechanisms and also toxicity of these plants in human subjects.


Leng, G.C., Lee, A.J., FOWKERS, F.G.R., WHITEMAN, M., Dunbar, J., Housley, E., Ruckley, C.V. 1996. Incidence, natural histo-ry and cardiovascular events in symptomatic and asymptomatic peripheral arterial disease in the general population. International jour-nal of epidemiology, 25: 1172-1181.

Abd Elwahaab, H.A. Rahmy, A.F. Hagag, A.A. Fares, H.M. & Fouad, Sh.A. (2019). Effect of Aerobic exercises on Blood coagulation and Fibrinolysis factors in Elderly Hypertensive patients. J Adv Pharm Edu Res, 9(1), pp. 44-48.

World Health Organisation New data high-light increases in hypertension, diabetes in-ci-dence.Availablefrom: (Accessed: 30/05/15).

Lawes CM, Vander Hoorn S, Rodgers A. Glob-al burden of blood-pressure-related disease, 2001. Lancet 2008; 371:1513–8.

MacMahon, S., Peto, R., Collins, R., Godwin, J., Cutler, J., Sorlie, P., Abbott, R., Neaton, J., Dyer, A., Stamler, J. 1990. Blood pressure, stroke, and coronary heart disease: part 1, prolonged differences in blood pressure: prospective observational studies corrected for the regression dilution bias. The Lancet, 335: 765-774.

Brook RD, Appel LJ, Rubenfire M, Ogedegbe G, Bisognano JD, Elliott WJ, et al. Beyond medica¬tions and diet: alternative approach-es to lowering blood pressure. J Hypertens 2013; 61:1360–83.

Sarafidis PA, Li S, Chen SC, Collins AJ, Brown WW, Klag MJ, et al. Hypertension awareness, treatment, and control in chronic kidney dis-ease. Am J Med 2008; 121:322–40.

Appel, L.J., Champagne, C.M., Harsha, D.W., Cooper, L.S., Obarzanek, E., Elmer, P.J., Ste-vens, V.J., Vollmer, W.M., Lin, P.-H., Svetkey, L.P. 2003. Effects of comprehensive lifestyle modification on blood pressure control: main results of the PREMIER clinical trial. Journal of the American Medical Association.

Collaboration, B.P.L.T.T. 2000. Effects of ACE inhibitors, calcium antagonists, and other blood-pressure-lowering drugs: results of prospectively designed overviews of ran-domised trials. The Lancet, 356: 1955-1964.

Mitaliya KD, Bhatt DC, Patel NK, Dodia SK. Herbal remedies used for hair disorders by tribals and rural folk in Gujarat. Indian J Tradit Know 2003; 2:389–92.

Snyder FJ, Dundas ML, Kirkpatrick C, Neill KS. Use and safety perceptions regarding herbal sup¬plements: a study of older per-sons in southeast Idaho. J Nutr Elder 2009; 28:81–95.

Tekol, Y., 2007. The medieval physician Avi-cenna used an herbal calcium channel block-er, Taxus baccata L. Phytotherapy Research, 21: 701-702.

Sayed Ahmad,M. Shawky, A. Ghobashy,M.O. & Ahmed Felifel, R.H. (2018). Effect of Some medicinal plants on life cycle of Citrus Brown Mites (Eutetranychusorientalis). In-ternational Journal of Pharmaceutical Re-search & Allied Sciences, 7(4), pp.13-17.

Ojewumi, M. E. Adeyemi, A. O. & Ojewumi, E. O. (2018). Oil extract from local leaves - an alternative to synthetic mosquito repel-lants. Pharmacophore, 9(2), pp. 1-6.

Mensah JK, Okoli RI, Turay AA, Ogie-Odia EA. Phytochemical analysis of medicinal plants used for the management of hyperten-sion by Esan people of Edo state, Nigeria. Ethnobot Leaflets 2009; 10:7.

World Health Organization. The use of herbal medicine in primary health care. In: Report of the Regional Meeting. 10–12 March 2009, Yangon, Myanmar. WHO, New Delhi, 2009. World Health Organization. In: Adherence to long term therapies: evidence for action. WHO, Geneva, Switzerland, 2003.

Sharma I, Parashar B, Dhamija HK, Sharma R. An ayurvedic arena for hypertension treat-ment. Asian J Pharmaceut Res 2012; 2:54–8.

Stockwell C. Nature’s pharmacy: a history of plants and healing. Random House, London, UK, 1988.

World Health Organization. WHO traditional medicine strategy 2014–2023. WHO, Geneva, Switzerland, 2013.

Bekut M., Brkić S., Kladar N., Dragović G., Gavarić N., Božin B. Potential of selected Lamiaceae plants in anti(retro)viral therapy. 2017 doi: 10.1016/j.phrs.2017.12.016.

Bouhabila, A. Zellagui, A. Telci, I. Maarfia, S. & Gherraf, N. (2018). Changeability of Essen-tial Oils in Algerian Mentha Rotundifolia L.(Lamiaceae) Growing in Sub Humid Area. World Journal of Environmental Bioscienc-es. 7(4).pp.45-47.

Ahmad L, Semotiuk A, Zafar M, Ahmad M, Sultana S, Liu QR, et al. Ethnopharmacologi-cal documen¬tation of medicinal plants used for hyperten¬sion among the local communi-ties of DIR Lower, Pakistan. J Ethnopharma-col 2015; 175:138–46.

Nortje, J. 2011. Medicinal ethnobotany of the Kamiesberg, Namaqualand, Northern Cape Province. MSc thesis. University of Johan-nesburg.

Philander, L. A. 2011. An ethnobotany of Western Cape Rasta bush medicine. Journal of ethnopharmacology. 138(2), 578-594.

Van-Wyk, B. E., Van Heerden, F., Van Oudtshoorn, B. 2005. Poisonous Plants of South Africa. Briza Publications, Pretoria.

Mintza Mi Nzue, A. P. 2009. Use and conser-vation status of medicinal plants in the Cape Peninsula, Western Cape Province of South Africa. Unpublished MSc thesis. Stellen-bosch: University of Stellenbosch.

Agrawal M, Nandini D, Sharma V, Chauhan NS. Herbal remedies for treatment of hyper-tension. Inte J Pharm Sci Res 2010; 1(5): 1-21.

Ahmad I, Jan S, Begum A, Wali S. Taxonomic diver¬sity and ethnobotanical characteristics of the family Lamiaceae of Swat, Khyber Pakhtunkhwa, Pakistan. Pak J Bot 2007; 39:699–710.

Amjad MS, Qaeem MF, Ahmad I, Khan SU, Chaudhari SK, Zahid MN, et al. Descriptive study of plant resources in the context of the ethno¬medicinal relevance of indigenous flora: a case study from Toli Peer National Park, Azad Jammu and Kashmir, Pakistan. PLoS One 2017; 12(2): e0171896. doi:10.1371/journal.pone.0171896.

Shah SA, Shah NA, Ullah S, Alam MM, Bad-shah H, Ullah S, et al. Documenting the indig-enous knowl¬edge on medicinal flora from communities resid¬ing near Swat River (Su-vastu) and in high moun¬tainous areas in Swat-Pakistan. J Ethnopharmacol 2016; 182:67–79.

Moffett RO. Sesotho Plant and Animal Names and Plants used by the Basotho. Bloemfon-tein: Sun Press; 2010

Moteetee A, van Wyk BE. The medical eth-nobotany of Lesotho. Bothalia 2011; 5: 209–228

Olorunnisola OS, Bradley G, Afolayan AJ. Ethnobotanical information on plants used for the management of cardiovascular dis-eases in Nkonkobe Municipality. S Afr J Med Plants Res 2011; 5: 4256–4260.

Alamgeer MS, Jabeen Q, Bashir S, Malik MNH, Khan HU, Rahman MSU, et al. Antihy-pertensive and toxicity studies of aqueous methanolic extract of Mentha longifolia L. J Anim Plant Sci 2013; 23(6):1622–27.

Gilani AH, Aziz N, Khan MA, Shaheen F, Ja-been Q, Siddiqui BS, et al. Ethnopharmaco-logical eval¬uation of the anticonvulsant, sedative and anti¬spasmodic activities of Lavandula stoechas L. J Ethnopharmacol 2000; 71:161–7.

Haq F. The ethno botanical uses of medicinal plants of Allai Valley, western Himalaya Pa-kistan, Int J Plant Res 2012; 2:21–34.

Li WG, Zhang XY, Wu YJ, Tian, X. Anti-inflammatory effects and mechanism of Po-lygonum paleaceam Wall extracts. Journal of Pharmacology and Clinic of Traditional Chi-nese Medicine 2002; 18:18–20.

Oliveira-Simoes CM, Ribeiro-do-Vale RM, Poli A, Nicolau M, Zanin M 1989. Pharmaco-logical investigation on Polygonum puncta-tumElliott extracts. Part I. Tests in vivo. J Pharm Belg 1989; 44: 275-284.

Tareen RB, Bibi T, Khan MA, Ahmad M, Zafar M. Indigenous knowledge of folk medicine by the women of Kalat and Khuzdar regions of Balochistan, Pakistan. Pak J Bot 2010; 42:1465–85.

Davids D, Gibson D, Johnson Q. Ethnobotan-ical survey of medicinal plants used to man-age high blood pressure and type 2 diabetes mellitus in Bitterfontein, Western Cape Prov-ince, South Africa. J Ethnopharmacol 2016; 194: 755–766

Ahmad L, Semotiuk A, Zafar M, Ahmad M, Sultana S, Liu QR, et al. Ethnopharmacologi-cal documen¬tation of medicinal plants used for hyperten¬sion among the local communi-ties of DIR Lower, Pakistan. J Ethnopharma-col 2015; 175:138–46.

Razmjouei D, Zarei Z, Akbari M. Ethnobotan-ical study of medicinal plants of Abadeh city in Fars province. Journal Plants Ecophysiol-ogy 2015; 7(3): 222-234.

Rajaeia P and Mohamadi N. Ethnobotanical Study of Medicinal Plants of Hezar Mountain Allocated in South East of Iran. Iranian Jour-nal of Pharmaceutical Research 2012; 11 (4): 1153-1167.

Mensah JK, Okoli RA, Turay AA, Ogie-Odia EA. Phytochemical Analysis of Medicinal Plants Used for the Management of Hyper-tension by Esan people of Edo State, Nigeria. Ethnobotanical Leaflets 13: 1273-87. 2009.

al-Sereiti M. R., Abu-Amer K. M., Sen P. Pharmacology of rosemary (Rosmarinus of-ficinalis Linn.) and its therapeutic potentials. 1999;37(2):124–130. [PubMed]

Poulter NR, Prabhakaran D, Caulfield M. Hy-pertension. Lancet 2015; 386: 801–812

Chow CK, Teo KK, Rangarajan S, Islam S, Gup-ta R, Avezum A, et al. Prevalence, awareness, treatment, and control of hypertension in ru-ral and urban communities in high, middle, and low-income countries. J Am Med Ass 2013; 310:959–68.

James PA, Oparil S, Carter BL, Cushman WC, Dennison-Himmelfarb C, Handler J, Lackland DT, Lefevre ML, Mackenzie TD, Ogedegbe O, Smith SC, Svetley LP, Taler SJ, Townsend RR, Wright JT, Narva AS, Ortiz E. 2014 Evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8). JAMA 2014; 311: 507–520. doi:10.1001/jama.2013.284427.

Nole T, Lionel TW, Cedrix TS, Gabriel AA. Ethnomedical and ethnopharmacological study of plants used for potential treatments of diabetes and arterial hypertension by in-digenous people in three phytogeography re-gions of Cameroon, Diabetes Case Rep 2016; 110:2.

Peterson JJ, Dwyer JT, Jacques PF, McCullough ML. Associations between fla-vonoids and cardiovascular disease inci-dence or mortality in European and US popu-lations. Nutr Rev. 2012 Sep;70(9):491-508.

Rodriguez E, Towers G, Mitchell J. Biological activities of sesquiterpene lactones. Phyto-chemistry. 1976;15:1573-80.

de P. Emerenciano V, S. Ferreira Z, Auxiliado-ra C. Kaplan M, R. Gottlieb O. A chemosys-tematic analysis of tribes of asteraceae in-volving sesquiterpene lactones and flavo-noids. Phytochemistry. 1987;26:3103-15.

Asadi-Samani M, Rafieian-Kopaei M, Azimi N. Gundelia: a systematic review of medici-nal and molecular perspective. Pak J Biol Sci. 2013; 16:1238- 1247.

da Silveira e Sá Rde C, Andrade LN, de Sousa DP. Ses¬quiterpenes from essential oils and anti-inflammato¬ry activity. Nat Prod Com-mun. 2015; 10:1767-74.

Zargham H, Zargham R.Tannin extracted from Sumac inhibits vascular smooth mus-cle cell migration. Mcgill J Med. 2008; 11(2): 119–123.

Zhou JY, Zhou SW. Isorhynchophylline: A plant alkaloid with therapeutic potential for cardiovascular and central nervous system diseases. Fitoterapia 2012; 83 (4): 617-626.

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