Evaluation of the Sub-Acute Toxicity Effects of Amygdalus Eburnea Spach Extract in Mice

To date, the use of medicinal herbs for therapeutic purposes is very common; however, it is required to find the scientific validations for their side effects. This study aimed at identifying the toxicity effects of Amygdalus eburnea Spach extract on hematological and biochemical parameters in mice. Toxicity effects of N. tripedale extract were assessed by evaluating the biochemical and hematological parameters of the treated mice after oral administration of A. eburnea extract at the doses of 250, 500, and 750 mg/kg for 14 days. The results demonstrated that A. eburnea extract at the tested doses did not have considerable toxicity on the biochemical parameters of ALT, AST, ALP, and bilirubin used for the assessment of the liver function, and also Cr and BUN for renal function as well as hematological parameters such as HGB, Hct, WBC, RBC, and PLT counts. But further investigations are compulsory to determine other toxicity features such as genotoxicity, and chronic toxicity.

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