Histopathological and Toxicological Study of Selenium Nanoparticles in BALB/C Mice

This study was aimed to evaluate the toxicity of biogenic Selenium nanoparticles (SeNPs) on hematological and some serum biochemical parameters and also its histopathological effects in liver tissue in mice. Forty-eight male BALB/c mice were also used to determine the toxicity effects of SeNPs (2.5, 5, 10, 20, and 30 mg/kg) on some serum biochemical parameters and also its histopathological effects in liver tissue in mice. Microscopic examination of tissue sections of liver under light microscope from mice treated with the Se NPs 2.5, 5, 10 and 20 mg/kg doses showed there is no significant pathological change in comparison with those of the control groups. However, there was occasional focal mononuclear lymphocytic cellular infiltration around the portal and hepatocellular degeneration in 30 mg/kg doses group. The findings demonstrated that orally administration of Se NPs at the doses of 2.5, 5, 10, 20, and 30 mg/kg for 14 days, had no significant toxicity on the serum hematological and clinical chemistry parameters. The obtained results confirmed that SeNPs at the tested doses had no significant toxicity on the liver and kidney organs and also against hematological parameters in mice. However supplementary investigations are required to determine other toxicity aspects such as genotoxicity, chronic toxicity.

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