Creative Commons License 2018 Volume 5 Issue 1

Histopathological and Toxicological Study of Selenium Nanoparticles in BALB/C Mice

Amir Keyhani, Hossein Mahmoudvand, Mojtaba Shakibaie, Amir Tavakoi Kareshk, Jalil Nejati, Seyed Reza Mirbadie, Saeed Sadooghian, Nima Firoozeh, Naser Ziaali

This study was aimed to evaluate the toxicity of biogenic Selenium nanoparticles (SeNPs) on hematological and some serum biochemical parameters and also its histopathological effects in liver tissue in mice. Forty-eight male BALB/c mice were also used to determine the toxicity effects of SeNPs (2.5, 5, 10, 20, and 30 mg/kg) on some serum biochemical parameters and also its histopathological effects in liver tissue in mice. Microscopic examination of tissue sections of liver under light microscope from mice treated with the Se NPs 2.5, 5, 10 and 20 mg/kg doses showed there is no significant pathological change in comparison with those of the control groups. However, there was occasional focal mononuclear lymphocytic cellular infiltration around the portal and hepatocellular degeneration in 30 mg/kg doses group. The findings demonstrated that orally administration of Se NPs at the doses of 2.5, 5, 10, 20, and 30 mg/kg for 14 days, had no significant toxicity on the serum hematological and clinical chemistry parameters. The obtained results confirmed that SeNPs at the tested doses had no significant toxicity on the liver and kidney organs and also against hematological parameters in mice. However supplementary investigations are required to determine other toxicity aspects such as genotoxicity, chronic toxicity.


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Entomology and Applied Science Letters is an international double-blind peer reviewed publication which publishes scientific research & review articles related to insects that contain information of interest to a wider audience, e.g. papers bearing on the theoretical, genetic, agricultural, medical and biodiversity issues. Emphasis is also placed on the selection of comprehensive, revisionary or integrated systematics studies of broader biological or zoogeographical relevance. In addition to full-length research articles and reviews, the journal publishes interpretive articles in a Forum section, Short Communications, and Letters to the Editor. The journal publishes reports on all phases of medical entomology and medical acarology, including the systematics and biology of insects, acarines, and other arthropods of public health and veterinary significance.

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Institute of Pharmaceutical Sciences (IPS) , University of Veterinary and Animal Sciences, Lahore Pakistan.
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Entomology and Applied Science Letters supports the submission of entomological papers that contain information of interest to a wider reader groups e. g. papers bearing on taxonomy, phylogeny, biodiversity, ecology, systematic, agriculture, morphology. The selection of comprehensive, revisionary or integrated systematics studies of broader biological or zoogeographical relevance is also important. Distinguished entomologists drawn from different parts of the world serve as honorary members of the Editorial Board. The journal encompasses all the varied aspects of entomological research.