2016 Volume 3 Issue 5

Wound healing potential of various successive fractions obtained from Aegle marmelos (AM) and Mucuna pruriens (MP) in acid burn wound models: An experimental animal study


Fedelic Ashish Toppo, Rajesh Singh Pawar
Abstract

Traditionally leaves of Aegle marmelos (Linn.) Correa (Rutaceae) and seeds of Mucuna pruriens Linn. (Fabaceae) are applied on cuts and wounds. We report the acid burned wound healing activities of sequential ethyl acetate, methanol and aqueous extracts of AM and MP in acid burn wound models in rats. Forty-eight Wistar-albino rats (220±20g) were divided into eight groups (n=6) and were subjected to acid burn (100 mm2) on the back of their necks. Animals were divided into control group, standard group and treatment groups. The hydrogel was applied topically once daily to the treatment groups. The parameters observed were epithelialization period, wound contraction % and histopathological analysis as indicative of the process of healing. After the 20th day of treatment, wound closure % was 77.75% in control group, for the standard group it was 100%, for the test group III, IV, V, VI, VII and VIII it was 86.21, 94.81, 93.43, 89.66, 94.63 and 80.74%,respectively.Test groups III,IV,VI and VII showed significant (p<0.01)improvement in wound contraction % in comparison to control group. Similarly the period of epithelialization also decreased significantly in test groups. All extracts facilitated the wound healing process as demonstrated by a decrease in the period of epithelialization and faster wound contraction in acid burn wounds. Ethyl acetate and methanolic extract seemed to have the most active component for healing the acid burned wound.

 

Keywords: Rejuvenate; Bel; Kiwanch; Ameliorated acid burns; Wistar-albino rats


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Entomology and Applied Science Letters is an international peer reviewed publication which publishes scientific research & review articles related to insects that contain information of interest to a wider audience, e.g. papers bearing on the theoretical, genetic, agricultural, medical and biodiversity issues. Emphasis is also placed on the selection of comprehensive, revisionary or integrated systematics studies of broader biological or zoogeographical relevance. Papers on non-insect groups are no longer accepted. In addition to full-length research articles and reviews, the journal publishes interpretive articles in a Forum section, Short Communications, and Letters to the Editor. The journal publishes reports on all phases of medical entomology and medical acarology, including the systematics and biology of insects, acarines, and other arthropods of public health and veterinary significance.
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