2018 Volume 5 Issue 4

5% Suspension of Albendazole Echinacea Magenta (Echinacea Pur-purea) Toxicometric Evaluation


Lopteva Maria Sergeevna, Kolesnikov Vladimir Ivanovich, Pushkin Sergey Viktorovich, Povetkin Sergey Nikolaevich, Marinicheva Marina Petrovna, Strogov Vladimir Viktorovich, Nagdalian Andrey Ashotovich
Abstract

The acute toxicity of 5% suspension of albendazole Echinacea Magenta (Echinaceapurpurea) was studied when administered orally to outbred white mice. To determine the characteristics of the suspension acute toxicity, it was administered to animals once with varying doses. The general condition and behavior of animals were observed during 14 days. The intoxication symptoms’ manifestation and possible death were noticed. The animals' death was observed within five days after the drug administration. The drug's acute toxicity characteristics were as follows: MPD -740 mg/kg of body weight, and LD50 – 2960 mg/kg of body weight, LD16 -1450,4 mg/kg, LD84– 6050 mg/ kg of body weight. In accordance with Russian State Standard 12.1.007-76, the drug belonged to the class 3 of danger (moderately toxic substance).


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Entomology and Applied Science Letters is an international peer reviewed publication which publishes scientific research & review articles related to insects that contain information of interest to a wider audience, e.g. papers bearing on the theoretical, genetic, agricultural, medical and biodiversity issues. Emphasis is also placed on the selection of comprehensive, revisionary or integrated systematics studies of broader biological or zoogeographical relevance. Papers on non-insect groups are no longer accepted. In addition to full-length research articles and reviews, the journal publishes interpretive articles in a Forum section, Short Communications, and Letters to the Editor. The journal publishes reports on all phases of medical entomology and medical acarology, including the systematics and biology of insects, acarines, and other arthropods of public health and veterinary significance.
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