Choline is considered mandatory to the animal organism and is utilized both as a building unit and as essential component in regulation of certain metabolic processes. Choline is tentatively classified as one of the B-complex vitamins even though it doesn't entirely satisfy the strict definition of a vitamin. Choline, unlike B vitamins, can be synthesized in the liver, is required in the body in greater amounts, and apparently functions as a structural constituent rather than as a coenzyme. Although, existence of choline in essential body constituents was recognized long before the first vitamin was discovered. Regardless of classification, choline is an essential nutrient for all livestock and a required dietary supplement for some species (poultry, swine). Choline is likewise an essential nutrient for humans, and studies have investigated the benefits of choline treatment for certain diseases, such as cancer and Alzheimer’s disease.
Keywords: Choline. Animal. B-complex Vitamins. Essential Nutrient.
Ansell, G.B., and Spanner, S. 1971. Biochem J. 122, 741.
Bell, J.M. 1985. Devel. Psychobiol. 18, 383.
Buchman, A.L., Dubin, M., Jenden, D., and Moukarzel, A. 1992. Gastroenterology 102, 1363.
Canty, D.J., and Zeisel, S.H. 1994. Nutr. Rev. 52, 327.
Chan, M.M. 1991. In Handbook of Vitamins (L.J. Machlin, ed.), 2nd Ed., p. 537. Marcel Dekker, New York.
Chao, C.K., Pomfret, E.A., and Zeisel, S.H. 1988. Biochem. J. 254, 33.
Childs, M.T., Bowlin, J.A., Ogilvie, J.T., Hazzard, W.R., and Albers, J.J. 1981. Atherosclerosis 38, 217.
Crawford, J.S., Griffith, M., Teekell, R.A., and Watts, A.B. 1969. Poult. Sci. 38, 620.
De La Huerga, J., and Popper, H. 1952. J. Clin. Invest. 31, 598.
Derilo, Y.L., and Balnave, D. 1980. Poult. Sci. 21, 479.
DuCoa L.P. 1994. In Choline Functions and Requirements, p. 91. DuPont/ConAgra Co., Higland, Illinois.
Harms, R.H., and Miles, R.D. 1984. Poult. Sci. 63, 1464.
Hegazy, E., and Schwenk, M. 1984. J. Nutr. 114, 2217.
Kim, Y., Miller, J.W., Da Costa, K., Nadeau, M. Smith, D. Selhub, J., Zeisel, S.H., and Mason, J.B. 1994. J. Nutr. 124, 2197.
Kuksis, A., and Mookerjea, S. 1984. In Present Knowledge in Nutrition (R.E. Olson, H.P. Broquist, C.O. Chichester, W.J. Darby, A.C. Kolbye, and R.M. Stalvey, eds.), p. 383. Nutrition Foundation, Washington, D.C.
Lombardi, B., Ugazio, G., and Raick, A. 1966. Am. J. Physiol. 210, 31.
Latshaw, J.D., and Jensen, L.S. 1972. J. Nutr 102, 749.
Miles, R.D., and Harms, R.H. 1983. In Proc. 1983 Florida Nutrition Conference, p.75. Gainesville, Florida.
Mikol, Y.G., Hoover, K.L., Creasia, D., and Poirier, L.A. 1983. Carcinogenesis. 4, 1619. Nutrient Requirements of Poultry. 1994. 9th Ed.
NRC. 1987. Vitamin Tolerance of Animals. National Academy of Sciences-National Research Council, Washington, D.C.
Pesti, G.M., Harper, A.E., and Sunde, M.L. 1980. Poult. Sci. 59, 1073.
Ruiz, N., Miles, R.D., and Harms, R.H. 1983. WPSA J. 39, 185.
Sanford, P.A., and Smyth, D.H. 1971. J. Physiol. (Lond.) 215, 769.
Scott, M.L., Nesheim, M.C., and Young, R.J. 1982. Nutrition of the Chicken, p. 119. Scott, Ithaca, New York.
Smith, C.M., Swase, M., Exton-Smith, A.N., Phillips, M.J., Overstall, P.W., Piper, M.E., and Bailey, M.R. 1978. Lancet. 2, 318.
Southern, L.L., Brown, D.R., Werner, D.D., and Fox, M.C. 1986. J. Anim. Sci. 62, 992.
Spires, H.R., Botts, R.L., and King, B.D. 1982. Syntex Research Report, Series A, No. 1.
Tapia Romero, E., Rojas, R.E., Arias, L.E., and Avila, G.E. 1985. In Resumenes ALPA 85 (C.F.Chicco, ed.), p. 49 (Abstr.). Acapulco, Mexico.
Zeisel, S.H., Costa, K.A., Franklin, P.D., Alexander, E.A., Lamont, J.T., Sheard, N.F., Beiser, A., and Costa, K.A. 1991. FASEB J. 5, 2093.
Wood, J.L., and Allison, R.G. 1982. Fed. Proc. 41, 3015.
Zeisel, S.H. 1990. J. Nutr. Biochem. 1, 332.
Wauben, P.M., and Wainwright, P.E. 1999. Nutr. Rev. 57, 35.