The goal of the present investigation was to evaluate the antinociceptive activity and acute toxicity of P. atlantica fruit extract in mice. Totally 104 NMRI mice were used in this study. The acute toxicity was evaluated for 2 days. Antinociceptive activity was performed using hot plate, tail-flick, and rotarod test. The LD50 values of the P. atlantica fruit extract 1.66 g/kg and the maximum non-fatal doses were 0.93 g/kg. The results revealed that in hot plate and tail-flick tests, P. atlantica fruit extract at the doses of 50, 150 and 350 mg/kg had an analgesic effect as dose-dependent, 30 minutes after administration; so that there was a significant difference between the groups receiving saline and the extract (p<0.05). The findings also showed that no significant (p>0.05) changes were observed with injecting P. atlantica fruit extract at the doses of 50, 150 and 350 mg / kg in sensory motor test. The results of the current investigation demonstrated the robust antinociceptive activity of P. atlantica fruit extract in mice. However, the exact mechanisms accountable for the pharmacologoical activities remain to be investigated.
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