2018 Volume 5 Issue 1

The Possible Ameliorative Mechanisms of Curcumin and/or Coenzyme Q10 Against Hyperthyroidism Induced Liver Damage in Rats


Hanan S. Alnahdi
Abstract

This investigation was designed to study the ameliorative mechanisms of curcumin (CUR) and /or coenzyme Q10 (CO Q10) in comparison to the antithyroid drug, carbamizole, against hyperthyroidism induced liver damage. Hyperthyroidism was induced in rats through injection of L-thyroxine (LT4, 0.3mg/kg) subcutaneously for 12 consecutive days. CUR (100mg/Kg) and /or CO Q10 (50mg/Kg) or carbamizole (30mg/kg) were administered to hyperthyroidism rats for 21 consecutive days simultaneously with LT4 administration. The results revealed that oral intake of CUR and /or CO Q10 or carbamizole to hyperthyroidism rats, significantly reduced the serum levels of thyroxine (T4) and triiodothyronine (T3) and boosted the level of thyroid–stimulating hormone (TSH) with respect to hyperthyroidism rats. The used agents also reduced the hepatic increase in malondialdehyde (MDA) and increased the levels of catalase and glutathione (GSH) in hyperthyroidism rats. In addition, treatment with CUR and /or CO Q10 or carbamizole  efficiently  attenuated the hepatic DNA damage, the hepatic increase in caspase-3, the serum elevation in tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), C-reactive protein (CRP) and vascular endothelial growth factor (VEGF) as well as the alteration in serum liver function indices namely alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and albumin in hyperthyroidism rats with respect to untreated ones. Liver histopathological and ultrastructural studies were also done to confirm the biochemical investigation.

Conclusion: The current work demonstrated that CUR and /or CO Q10 were effective in mitigating hyperthyroidism induced liver damage. Carbimazole was the least efficient in reversing liver damage, however the combination of CUR and CO Q10 was the beneficial one in restoring hyperthyroidism induced liver dysfunction.


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Entomology and Applied Science Letters is an international peer reviewed publication which publishes scientific research & review articles related to insects that contain information of interest to a wider audience, e.g. papers bearing on the theoretical, genetic, agricultural, medical and biodiversity issues. Emphasis is also placed on the selection of comprehensive, revisionary or integrated systematics studies of broader biological or zoogeographical relevance. Papers on non-insect groups are no longer accepted. In addition to full-length research articles and reviews, the journal publishes interpretive articles in a Forum section, Short Communications, and Letters to the Editor. The journal publishes reports on all phases of medical entomology and medical acarology, including the systematics and biology of insects, acarines, and other arthropods of public health and veterinary significance.
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Entomology and Applied Science Letters supports the submission of entomological papers that contain information of interest to a wider reader groups e. g. papers bearing on taxonomy, phylogeny, biodiversity, ecology, systematic, agriculture, morphology. The selection of comprehensive, revisionary or integrated systematics studies of broader biological or zoogeographical relevance is also important. Distinguished entomologists drawn from different parts of the world serve as honorary members of the Editorial Board. The journal encompasses all the varied aspects of entomological research. This has become the need felt in scientific research due to the emphasis on intra-, inter-, and multi-disciplinary approach.