2016 Volume 3 Issue 4

Magnetic iron oxide nanoparticles solid phase extraction of erythromycin Extraction and determination of erythromycin in aqueous samples using magnetic

Najmeh Dibaei, Mahmoud Ebrahimi, Abolghasem Davoodnia

Erythromycin (ERY) is a macrolide antibiotic that has similar antimicrobial spectrum to penicillin and it is many used, particular in the treatment of patients who are allergic to penicillin. A simple, efficient and low-cost method based on matrix solid-phase dispersion (MSPD) microextraction was developed for the determination of erythromycin in environmental samples. In this work, Fe3O4 nanoparticles were adsorbents and spectrophotometric methods have been developed and validated for the isolation and pre-concentration of erythromycin form aquatic. The experimental conditions for the extraction, including Fe3O4 nanoparticle dosage, amount of the salt, the extraction time, and pH were investigated and optimized. Under the optimized conditions, a linear range of 10 -50000μgL−1 with R2 = 0.9551 and detection limit of 17 μg L-1 were obtained for target analyte. The method was successfully used for the extraction of ERY from aqueous samples with relative recoveries amount of 94.8 (RSDs =4.4). These results corroborate that this method is low cost, conveniently fast and prepare reliable results in order to be used in detection of erythromycin from aqueous samples.



Keywords: Erythromycin, spectrophotometry, nanoparticles, antibiotic


K. Griessmann, A. Kaunzinger, M. Schubert-Zsilavecz, M. Abdel-Tawab. Pharm. Sci. 2007; 62: 668.

R. Rattana poltaveechai, W. Vongkom, W. Suntornsuk, L. Suntornsuk. Food Drug Anal. 2007; 15.

M. Ali, S. Sherazi, S. Mahesar. Arab. J Chem. 2004; 7: 1104.

W. Zheng, K. Chen, J. Zhu, L. Ji. Sep. Purif. Technol. 2013; 116: 398.

K. Tsuji, M.P. Kane. Pharm.Sci. 1982; 71: 1160.

B. Liawruangrath, S. Liawruangrath. Chromatographia, 2001; 54: 405.

J. Wardrop, D. Ficker, S. Franklin, R.J. Gorski. Pharm. Sci. 2000; 89: 1097.

N. Gunes, R. Cibik, M.E. Gunes,L. Aydin. Food Addit. Contam. 2008; 25: 1313.

S.T. Hassib, A.E. Farag, E.F. Elkady. Bull. Fac. Pharm. CairoUniv. 2011; 49: 81.

T. Cachet, M. Delrue, J. Paesen, R. Busson, E. Roets, J. Hoogmartens. Pharm. Biomed. Anal. 1992; 10: 851.

R. Granja, A.M. Nio, R. Zucchetti, R.M. Nio, R. Patel, A.G. Salerno. AOACInt. 2009; 92: 975.

C. Benetti, R. Piro, G. Binato, R. Angeletti, G. Biancotto. Food Addit. Contam. 2006; 23: 1099.

J. Wang, D. Leung. RapidCommun. MassSpectrom. 2007; 21: 3213.

Y.-X. Li, K. Neufeld, J. Chastain, A. Curtis, P. Velagaleti. Pharm. Biomed. Anal. 1998; 16: 961.

A. Lalloo, I. Kanfer. Chromatogr. B:Biomed. Sci. Appl. 1997; 704: 343.

P.T.T. Ha, A. Van Schepdael, E. Roets, J. Hoogmartens. Pharm. Biomed. Anal. 2004; 34: 861–870.

Y.-C. Feng, C.-Q. Hu. Pharm. Biomed. Anal. 2006; 41: 373.

J. Tepe, C. JohnSt. Anal. Chem. 1955; 27: 744.

X. Hu, P. Wang, J. Yang, B. Zhang, J. Li, J. Luo, K. Wu. Colloids Surf. B:Biointerfaces, 2010; 81: 27.

M.A. Ivić, S. Petrović, D. Mijin, F. Vanmoos, D. Orlović, D. Marjanović, V. Radović. Electrochim. Acta. 2008; 54: 649.

W. Lian, S. Liu, J. Yu, X. Xing, J. Li, M. Cui, J. Huang. Biosens.Bioe- lectron. 2012; 38: 163.

A. Khodabakhshi, M.M. Amin, M. Mozaffari. Iran. J. Environ. Health. Sci. Eng. 2011; 8: 189.

J. Qu, J. Environ. Sci. 2008; 20: 1.

M. Ghaemi, G. Absalan. Microchim. Acta. 2014; 181: 45.

A. Afkhami, R. Moosavi, J. Hazard. Mater. 2010; 174: 398.

S. Qadri, A. Ganoe, Y. Haik, J. Hazard. Mater. 2009; 169: 318.

S. Pirillo, M. Ferreira, E.H. Rueda, Ind. Eng. Chem. Res. 2007; 46: 8255

B. A. Bolto. Waste Management. 1990; 10: 11.

A. B. Fuertes and P. Tartaj. Chem. Mater. 2008; 18: 1675.

T. Yang, S. H. Zhu, D. Zhang, and S. H. Xu. Mater. Lett. 2008; 62: 645.

S. Liong. Georgia Institut of Technology, North Ave, Atlanta, Georgia. 2005; 213.

M. Senthil and C. Ramesh. Nanomaterials and Biostructures. 2012; 7: 1655.

Cornell RM, Schwertmann U. The Iron Oxide: Structure, Properties, Reactions, Occurrence and Uses. 1996.

S. Pal. Tetrahedron, 2006; 62: 3171.

E.F. Fiese, S.H. Steffen. Antimicrobial Chemotherapy, 1990; 25: 39.

D.A. Volmer, J.P.M. Hui. Rapid communications in mass spectrometry, 1998; 12: 123.

A.Mohammadi , Y.Yamini ,N. Alizadeh. Chromatogr, 2005; A: 1063


Entomology and Applied Science Letters is an international peer reviewed publication which publishes scientific research & review articles related to insects that contain information of interest to a wider audience, e.g. papers bearing on the theoretical, genetic, agricultural, medical and biodiversity issues. Emphasis is also placed on the selection of comprehensive, revisionary or integrated systematics studies of broader biological or zoogeographical relevance. Papers on non-insect groups are no longer accepted. In addition to full-length research articles and reviews, the journal publishes interpretive articles in a Forum section, Short Communications, and Letters to the Editor. The journal publishes reports on all phases of medical entomology and medical acarology, including the systematics and biology of insects, acarines, and other arthropods of public health and veterinary significance.
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Entomology and Applied Science Letters supports the submission of entomological papers that contain information of interest to a wider reader groups e. g. papers bearing on taxonomy, phylogeny, biodiversity, ecology, systematic, agriculture, morphology. The selection of comprehensive, revisionary or integrated systematics studies of broader biological or zoogeographical relevance is also important. Distinguished entomologists drawn from different parts of the world serve as honorary members of the Editorial Board. The journal encompasses all the varied aspects of entomological research. This has become the need felt in scientific research due to the emphasis on intra-, inter-, and multi-disciplinary approach.