Toxicity Effect of Nectaroscordum tripedale Extract on Hematological and Biochemical Parameters in Mice

Ali Asghar Kiani, Behrouz Ezatpour, Massumeh Niazi, Sareh Jahanbakhsh


Currently, a broad spectrum of medicinal herbs is existing; while this seems to be necessary to present scientific validations for finding their side effects for therapeutic goals. In this study, the toxicity effects of Nectaroscordum tripedale extract on hematological and biochemical parameters in mice were assessed. Toxicity effects of N. tripedale extract was assessed by measuring the biochemical and hematological parameters of the treated mice after oral administration of N. tripedale extract at the doses of 0.5, 1, and 2 g/kg, respectively, for two weeks. The obtained results of the present investigation revealed that N. tripedale extract at the tested doses had no significant toxicity on the biochemical parameters of ALT, AST, ALP, and bilirubin for the liver function, and also Cr and BUN for renal function as well as hematological parameters such as HGB, Hct, WBC, RBC, and PLT counts. However additional studies are mandatory to assess other toxicity aspects such as genotoxicity, chronic toxicity.

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Cosa P, Vlietinck AJ, Berghe DV, Mae L. Anti-infective potential of natural products: How to develop a stronger in vitro ‘proof-of-concept’. J Ethnopharmacol 2006; 106: 290-302. 2.

Mahmoudvand H, Asadi A, Harandi MF, Sharififar F, Jahanbakhsh S, Dezaki ES. In vitro lethal effects of various extracts of Nigella sativa seed on hydatid cyst protoscoleces.Iran J Basic Med Sci. 2014c: 17(12): 1001-6.

Cowan MM. Plant products as antimicrobial agents. Clin Microb Rev 1999; 12:564-82.

Saedi Dezaki E, Mahmoudvand H, Sharififar F, Fallahi S, Monzote L, Ezatkhah F. Chemical composition along with anti-leishmanial and cytotoxic activity of Zataria multiflora. Pharm Biol. 2016;54(5):752-8.

Jahanbakhsh S, Azadpour M, Tavakoli Kareshk A, Keyhani A. Mahmoudvand H. Zataria multiflora Bioss: lethal effects of methanolic extract against protoscoleces of Echinococcus granulosus. J Parasit Dis 2015, DOI 10.1007/s12639-015-0670-4.

Mozaffarian V. Trees and Shrubs of Iran, Farhang Moaser, Tehran, Iran, 1st edition, 2005.

Shafie-Zadeh F. Lorestan medicinal plants. Lorestan University of Medical Sciences. Tehran: Hayyan press; 2002.

Ezatpour B, Azami M, Motamedi M, Rashidipour M, Mahmoudvand H, Alirezaei M, et al. Chemical Composition, in Vitro Antibacterial and Cytotoxicity Effect of Nectaroscordum tripedale Extract. Herb. Med. J. 2016;1(1):29-36.

Mahmodvand H, Torkashvand M, Kheirandish F, Ezatpour B, Mirbadie SR, Jahanbakhsh S. Assessment of the In Vitro antileishmanial and cytotoxic activity of Nectaroscordum tripedale fruit extract. Entomology and Applied Science Letters, 2016, 3, 3S:1-5

Mahmoudvand H, Ezatpour B, Rashidipour M, Mirbadie SR, Mahmoudvand H. Report: Evaluation of the scolicidal effects of Nectaroscordum tripedale extract and its acute toxicity in mice model. Pak J Pharm Sci. 2016;29(6):2125-2128.

Diskin CJ, Tomasso CL, Alper JC, Glaser ML, Fliegel SE. Longterm selenium exposure. Arch Intern Med 1979; 139: 824-6.

Fallahi S, Beyranvand M, Mahmoudvand H, Nayebzadeh H, Kheirandish F, Jahanbakhsh S. Chemical composition, acute and sub-acute toxicity of Satureja khuzestanica essential oil in mice. J.Res.Pharm. 2017; 21(3): 515-521.

Kheirandish F, Delfan B, Mahmoudvand H, Moradi N, Ezatpour B, Ebrahimzadeh F, Rashidipour M. Antileishmanial, antioxidant, and cytotoxic activities of Quercus infectoria Olivier extract. Biomed Pharmacother. 2016;82:208-15.

Mahmoudvand H, Sharififar F, RahmatMS, Tavakoli R, Dezaki ES, Jahanbakhsh S, Sharifi I. Evaluation of antileishmanial activity and cytotoxicity of the extracts of Berberis vulgaris and Nigella sativa against Leishmaniatropica. J Vector Borne Dis. 2014: 51(4): 294-9.

Mahmoudvand H, Mahmoudvand H, Oliaee RT, Kareshk AT, Mirbadie SR, Aflatoonian MR. In vitro Protoscolicidal Effects of Cinnamomum zeylanicum Essential Oil and Its Toxicity in Mice. Pharmacogn Mag. 2017;13(Suppl 3):S652-S657.

Mahmoudvand H, Tavakoli Oliaei R, Mirbadie SR3, Kheirandish F, Tavakoli Kareshk A, Ezatpour B, Mahmoudvand H. Efficacy and Safety of Bunium Persicum (Boiss) to Inactivate Protoscoleces during Hydatid Cyst Operations. Surg Infect (Larchmt). 2016;17(6):713-719.

Mahmoudvand H, Kheirandish F, Dezaki ES, Shamsaddini S, Harandi MF. Chemical composition, efficacy and safety of Pistacia vera (var. Fandoghi) to inactivate protoscoleces during hydatid cyst surgery. Biomed Pharmacother. 2016;82:393-8.

Mahmoudvand H, Fallahi S, Mahmoudvand H, Shakibaie M, Harandi MF, Dezaki ES. Efficacy of Myrtus communis L. to Inactivate the Hydatid Cyst Protoscoleces. J Invest Surg. 2016; 29(3):137-43.

Lawal B, KudiratShittu O, Oibiokpa FI, Mohammed H, ItopaUmarS, Muhammed Haruna G. Antimicrobial evaluation, acute and sub-acute toxicity studies of Allium sativum. Journal of Acute Disease. 2016; 5 (4): 296-301.



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<Entomology+Zoology+Allied Branches>Entomology and Applied Science Letters