Evaluation of the Sub-Acute Toxicity Effects of Amygdalus Eburnea Spach Extract in Mice

Mahdi Rezaeifar, Maryam Rezaeifar

Abstract


To date, the use of medicinal herbs for therapeutic purposes is very common; however, it is required to find the scientific validations for their side effects. This study aimed at identifying the toxicity effects of Amygdalus eburnea Spach extract on hematological and biochemical parameters in mice. Toxicity effects of N. tripedale extract were assessed by evaluating the biochemical and hematological parameters of the treated mice after oral administration of A. eburnea extract at the doses of 250, 500, and 750 mg/kg for 14 days. The results demonstrated that A. eburnea extract at the tested doses did not have considerable toxicity on the biochemical parameters of ALT, AST, ALP, and bilirubin used for the assessment of the liver function, and also Cr and BUN for renal function as well as hematological parameters such as HGB, Hct, WBC, RBC, and PLT counts. But further investigations are compulsory to determine other toxicity features such as genotoxicity, and chronic toxicity.


Full Text:

PDF

References


Cosa P, Vlietinck AJ, Berghe DV, Mae L. Anti-infective potential of natural products: How to develop a stronger in vitro ‘proof-of-concept’. J Ethnopharmacol 2006; 106: 290-302. 2.

Mahmoudvand H, Asadi A, Harandi MF, Sharififar F, Jahanbakhsh S, Dezaki ES. In vitro lethal effects of various extracts of Nigella sativa seed on hydatid cyst protoscoleces. Iran J Basic Med Sci. 2014c: 17(12): 1001-6.

Rocha LG, Almeida JR, Macedo RO, Barbosa-Filho JM. A review of natural products with antileishmanial activity. Phytomedicin 2005; 12: 514-535.

Madani B, Rahemi M, Baninasab B, Mahmoodi M. Morphological evaluation of three native species of Amygdalus in iran. Hortic Environ Biotechnol 2009;50(1):63-7.

Rezaeifar M, Behfarnezhad M, Moradi M, Mehrabani M, Mahmoudvand H. Antibacterial effects of various extracts of Amygdalus eburnea on some most common bacteria in burning. Der Pharm Lett 2016b;8(6):110-2.

Rezaeifar M, Mahmoudvand H, Amiria M. Formulation and evaluation of diphenhydramine gel using different gelling agents. Der Pharm Chem 2016e;8(5):243-9.

Rezaeifar M, Rezaeifar M. Antioxidant properties of the methanolic extract of the shell root of Amygdalus eburnean. Int J Pharmtech Res 2016d;9(9):514-8.

Rezaeifar M, Rezaeifar M. In vitro antidermatophytic effects of the methanolic extract of the Amygdalus eburnean. Int J Pharmtech Res 2016c;9(9):509-12.

Rezaeifar R, Mousavi SA, Mehrabani M, Sepahvand A. Evaluation of the antifungal effects of various extracts of Amygdalus eburnean on some fungal pathogens. Der Pharm Chem 2016a;8(6):140-2.

Diskin CJ, Tomasso CL, Alper JC, Glaser ML, Fliegel SE. Longterm selenium exposure. Arch Intern Med 1979; 139: 824-6.

Fallahi S, Beyranvand M, Mahmoudvand H, Nayebzadeh H, Kheirandish F, Jahanbakhsh S. Chemical composition, acute and sub-acute toxicity of Satureja khuzestanica essential oil in mice. J.Res.Pharm. 2017; 21(3): 515-521.

Mahmoudvand H, Nadri S, Jahanbakhsh S, Rezaeifar M. Evaluations of protoscolicidal activity of Cardamom extract against hydatid cyst protoscoleces. Der Pharm Chem 2016;8(6):91-5.

Mahmoudvand H, Nadri S, Rezaeifar M, Rezaeifar M. Scolicidal effects of myrtle methanolic extract on hydatid cyst protoscoleces. Der Pharm Lett 2016;7(8):27-30.

Tavakoli Kareshk A, Keyhani A, Mahmoudvand H, Tavakoli Oliaei R, Asadi A, Andishmand M, et al. Efficacy of the Bunium persicum (Boiss) essential oil against acute toxoplasmosis in mice model. Iran J Parasitol 2015;10:625-31.

Mahmoudvand H, Mahmoudvand H, Oliaee RT, Kareshk AT, Mirbadie SR, Aflatoonian MR. In vitro Protoscolicidal Effects of Cinnamomum zeylanicum Essential Oil and Its Toxicity in Mice. Pharmacogn Mag. 2017;13(Suppl 3):S652-S657.

Mahmoudvand H, Tavakoli Oliaei R, Mirbadie SR3, Kheirandish F, Tavakoli Kareshk A, Ezatpour B, Mahmoudvand H. Efficacy and Safety of Bunium Persicum (Boiss) to Inactivate Protoscoleces during Hydatid Cyst Operations. Surg Infect (Larchmt). 2016;17(6):713-719.

Mahmoudvand H, Kheirandish F, Dezaki ES, Shamsaddini S, Harandi MF. Chemical composition, efficacy and safety of Pistacia vera (var. Fandoghi) to inactivate protoscoleces during hydatid cyst surgery. Biomed Pharmacother. 2016;82:393-8.

Mahmoudvand H, Fallahi S, Mahmoudvand H, Shakibaie M, Harandi MF, Dezaki ES. Efficacy of Myrtus communis L. to Inactivate the Hydatid Cyst Protoscoleces. J Invest Surg. 2016; 29(3):137-43.

Mehrabani M, Modirian E, Ebrahimabadi AR, Vafazadeh J, Shahnavaz S, Heidari MR. Study of the Effects of hydro-methanol extracts of lavandula vera DC. and cuscuta epithymum murr. on the seizure induced by pentylentetranzol in Mice. Journal of Kerman University of Medical Sciences.2007;14(1):44-54.

Loomis TA, Essential of Toxicology, Lea and Febige, Philadelphia, 1968.




URN: http://nbn-resolving.de/urn:nbn:de:0000easl.v5i1.2467

Refbacks

  • There are currently no refbacks.




Copyright (c) 2018 Mahdi Rezaeifar, Maryam Rezaeifar

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

<Entomology+Zoology+Allied Branches>Entomology and Applied Science Letters